LK Plus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Pacific pharmaceuticals ltd

Title

LK Plus

Categories

  • Medicine
  • Healthcare
  • Pharmaceutical

Description

Losartan and Hydrochlorothiazide combination for the treatment of hypertension and reduction of stroke risk in patients with hypertension and left ventricular hypertrophy.

Dimensions

  • Tablet size: Varies
  • Packaging size: Varies

Color options

N/A

Functions

  • Antihypertensive
  • Diuretic
  • Stroke risk reduction

Materials

  • Losartan
  • Hydrochlorothiazide

Technical specifications

  • Losartan concentration:
    • 50mg
    • 100mg
  • Hydrochlorothiazide concentration:
    • 12.5mg
    • 25mg
  • Storage temperature: Below 30°C

Design elements

  • Tablet shape: Varies
  • Tablet coating: Varies

Usability features

  • Administration with food: 1
  • Antihypertensive combination: 1

Indications

  • Treatment of hypertension
  • Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy

Pharmacology

  • Mechanism of action:
    • Block angiotensin II binding to AT1 receptor
    • Inhibit vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Effects on electrolyte reabsorption:
    • Increased excretion of Sodium and Chloride
    • Reduction in plasma volume

Dosage

  • Hypertension:
    • Starting dose: 50/12.5mg once daily
    • Maximum dose: 100/25mg once daily
    • Antihypertensive effect onset: Within three weeks
    • Elderly patients initial dose adjustment: Not necessary for 50/12.5mg, avoid 100/25mg as initial therapy
  • Severe hypertension:
    • Starting dose: 50/12.5mg once daily
    • Maximum dose: 100/25mg once daily

Interaction

  • Losartan potassium:
    • No significant drug-drug interactions found
    • Potential increase in serum potassium with potassium-sparing diuretics
  • Hydrochlorothiazide:
    • Potential interaction with alcohol, barbiturates, narcotics
  • Antidiabetic drugs: Dosage adjustment may be required
  • Other antihypertensive drugs: Additive effect or potentiation
  • Cholestyramine colestipol resins: Impaired absorption of Hydrochlorothiazide

Contraindications

  • Hypersensitivity: To any component of the product
  • Anuria or sulfonamide-derived drug hypersensitivity: 1

Side effects

  • Symptomatic hypotension
  • Hyperkalaemia
  • Angioedema
  • Vertigo
  • Gastrointestinal disturbances
  • Headache
  • Rash
  • Hepatitis
  • Anaphylaxis
  • Renal impairment
  • Rhabdomyolysis
  • Photosensitivity

Pregnancy lactation

  • Avoid in pregnancy: 1
  • Limited information on breastfeeding: Not recommended
  • Alternative treatment options: Available

Precautions warnings

  • Periodic serum electrolyte monitoring
  • Risk of hypokalemia
  • Impaired renal function
  • Impaired hepatic function

Special populations

  • Renal impairment: Use with caution, preference for loop diuretics
  • Hepatic impairment: Not recommended
  • Pediatric use: Safety and effectiveness not established

Overdose effects

  • Losartan potassium: Likely hypotension and tachycardia
  • Hydrochlorothiazide: Electrolyte depletion, potential accentuation of cardiac arrhythmias

Therapeutic class

Combined antihypertensive preparations

Storage conditions

Below 30°C, Keep out of the reach of children

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