Rivas 1.5 mg (Capsule)
Unit Price: ৳ 23.00 (2 x 10: ৳ 460.00)
Strip Price: ৳ 230.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rivastigmine tartrate |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Symptomatic treatment of mild to moderately severe Alzheimer's dementia
- Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease
Pharmacology
- Carbamate derivative structurally related to physostigmine
- Binds reversibly with and inactivates cholinesterase
- Increases concentration of acetylcholine at cholinergic synapses
- Relatively specific for brain acetylcholinesterase and butyrylcholinesterase
Dosage
- Initial dose: Rivastigmine 1.5 mg twice a day
- Dose titration based on good tolerability
- Maintenance dose: 3 mg to 6 mg twice a day
- Re-initiation of therapy: 1.5 mg twice daily
- Transdermal patch: 4.6 mg/24 hours initial dose
- Patch replacement every 24 hours
- Dose titration for patch after minimum weeks
Administration
- Administered twice a day with morning and evening meals
Interaction
- Exaggerates effects of succinylcholine-type muscle relaxants
- Caution required in selecting anaesthetic agents
- Should not be given concomitantly with other cholinomimetic substances
- No pharmacokinetic interaction with certain drugs observed
Contraindications
- Contraindicated in patients with hypersensitivity to the active substance or other carbamate derivatives
Side Effects
- Most commonly reported adverse reactions are gastrointestinal including nausea and vomiting, especially during titration
- Female patients more susceptible than male patients to gastrointestinal adverse reactions and weight loss
Pregnancy & Lactation
- Should not be used during pregnancy unless clearly necessary
- Excreted into milk in animals
- Not known if excreted into human milk, therefore women on rivastigmine should not breast-feed
Precautions & Warnings
- Caution in patients with certain conditions like sick sinus syndrome, conduction defects, respiratory diseases, asthma, or obstructive pulmonary disease
- Monitoring of body weight, exacerbation of urinary obstruction and seizures possible
Use in Special Populations
- Dosing recommendations for renal and hepatic impairment
- Not recommended for use in children
Overdose Effects
- Most cases of accidental overdose have not been associated with clinical signs or symptoms
- Symptoms may include nausea, vomiting, diarrhea, hypertension, hallucinations
- Bradycardia and/or syncope may occur
- Recommendations for management in case of overdose provided
Therapeutic Class
- Drugs for Dementia
Storage Conditions
- Store in a cool and dry place, protected from light