Losacard HZ 50 mg+12.5 mg (Tablet)
Unit Price: ৳ 8.03 (30's pack: ৳ 240.92)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium hydrochlorothiazide |
| Company | Novo healthcare and pharma ltd |
Indications
- Treatment of hypertension
- Risk reduction of stroke in patients with hypertension and left ventricular hypertrophy
Pharmacology
- Losartan and its active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II
- Hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption
Dosage
- Usual starting dose of 50/12.5 is one tablet once daily
- Maximum dose is 100/25 once daily
- Antihypertensive effect is attained within three weeks after initiation of therapy
Administration
May be administered with or without food
Interaction
- No significant drug-drug interactions found in interaction studies with certain drugs
- Potentiation of orthostatic hypotension may occur with concurrent administration of certain drugs
- Dosage adjustment of antidiabetic drugs may be required when administered concurrently with Hydrochlorothiazide
Contraindications
- Hypersensitivity to any component of the product
- Anuria or hypersensitivity to other sulfonamide-derived drugs
Side Effects
- Symptomatic hypotension including dizziness
- Hyperkalaemia
- Angioedema
- Vertigo
- Gastro-intestinal disturbances
- Headache
- Rash
- Pancreatitis
- Anaphylaxis
Pregnancy & Lactation
- Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential
- Not recommended in breastfeeding
Precautions & Warnings
- Periodic determination of serum electrolytes
- Hypokalemia may rarely develop
- Impaired renal function
- Symptomatic hypotension
Use in Special Populations
- Use in Patients with Renal Impairment
- Use in Patients with Hepatic Impairment
- Use in pediatric patients
Overdose Effects
- Manifestations of overdosage include hypotension, tachycardia, and bradycardia
- Supportive treatment should be instituted if symptomatic hypotension occurs
Therapeutic Class
Combined antihypertensive preparations
Storage Conditions
Do not store above 30°C. Keep out of the reach of children