Relacef Plus 500 mg+125 mg (Tablet)

Unit Price: ৳ 48.00 (7's pack: ৳ 336.00)

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Cosmic pharma ltd
Also available as
Relacef plus 250 mg tablet

Title, Categories, and Description

  • Relacef Plus 500 mg Tablet
  • Medicine
  • Cephalosporin Antibiotic and Beta-lactamase Inhibitor for Bacterial Infections

Dosage & Administration

  • 250 mg b.i.d. for 5-10 days for Pharyngitis/Tonsillitis in Adults
  • 250 mg b.i.d. for 10 days for Acute Bacterial Maxillary Sinusitis in Adults
  • 250-500 mg b.i.d. for 10 days for Acute Bacterial Exacerbation of Chronic Bronchitis in Adults
  • 250-500 mg b.i.d. for 5-10 days for Secondary Bacterial Infections of Acute Bronchitis in Adults
  • 250-500 mg b.i.d. for 10 days for Uncomplicated Skin and Skin Structure Infections in Adults
  • 250 mg b.i.d. for 7-10 days for Uncomplicated Urinary Tract Infections in Adults
  • 1000 mg b.i.d. Single dose for Uncomplicated Gonorrhoea in Adults
  • 250-500 mg b.i.d. for 5-10 days for Community Acquired Pneumonia in Adults
  • 500 mg b.i.d. for 10-14 days for MDR Typhoid Fever in Adults
  • 500 mg b.i.d. for 20 days for Early Lyme Disease in Adults
  • 20 mg/kg/day b.i.d for 5-10 days for Pharyngitis/Tonsillitis in Paediatric Patients
  • 30 mg/kg/day b.i.d for 10 days for Acute Otitis Media in Paediatric Patients
  • 30 mg/kg/day b.i.d for 10 days for Acute Bacterial Maxillary Sinusitis in Paediatric Patients
  • 30 mg/kg/day b.i.d for 10 days for Impetigo in Paediatric Patients

Pharmacology

Bactericidal second generation cephalosporin antibiotic active against a wide range of Gram-positive and Gram-negative susceptible organisms. Inhibits bacterial cell wall synthesis by interfering with the transpeptidation process. Clavulanic acid is a beta lactamase inhibitor that protects Cefuroxime from degradation by beta lactamase enzymes.

Indications

  • Pharyngitis/Tonsillitis
  • Acute Bacterial Otitis Media
  • Acute Bacterial Maxillary Sinusitis
  • Lower Respiratory Tract Infections
  • Acute Bacterial Exacerbation of Chronic Bronchitis
  • Uncomplicated Skin and Skin-Structure Infections
  • Uncomplicated Urinary Tract Infections
  • Bone and Joint Infections
  • Uncomplicated Gonorrhoea
  • Early Lyme Disease
  • Septicemia
  • Meningitis
  • Switch Therapy (Injectable to Oral)

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Contraindications

Patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Prolonged administration may result in overgrowth of nonsusceptible microorganisms
  • Rarely (<0.2%) renal dysfunction
  • Anaphylaxis
  • Angioedema
  • Pruritis
  • Rash
  • Serum sickness like urticaria

Pregnancy & Lactation

Avoid in the first trimester if possible. Can be safely used in later pregnancy to treat urinary and other infections. Excreted into breast milk in small quantities.

Precautions & Warnings

  • Given with care to patients receiving concurrent treatment with potent diuretics
  • History of colitis

Therapeutic Class

Second generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Common Questions about Relacef Plus 500 mg Tablet

  • Used to treat infections caused by sensitive bacteria
  • Indicated for pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever
  • Starts working within 2-3 hours after taking it
  • Lasts for an average duration of 4-8 hours
  • Interaction with alcohol is unknown
  • Not habit-forming
  • Safe to use in pregnancy and breastfeeding
  • Do not skip doses and finish the full course of treatment
  • Take with food to avoid an upset stomach
  • Stop taking if itchy rash, swelling, or breathing difficulties develop
  • Do not use leftover medicine for future infections

Pharmacological Actions

Bactericidal, Interferes with transpeptidation process, Inhibits bacterial cell wall synthesis, Beta lactamase inhibition, Protects Cefuroxime from degradation

Usability Features

  • Safe to use in pregnancy
  • Safe to use during breastfeeding

Technical Specifications

  • Store below 30°C
  • Bactericidal action against Gram-positive and Gram-negative organisms

Design Elements

  • Cephalosporin/Clavulanic Acid Combination

Materials

  • Cefuroxime
  • Clavulanic Acid

Functions

  • Bactericidal action
  • Inhibits bacterial cell wall synthesis
  • Interferes with the transpeptidation process

Dimension

500 mg Tablet

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