G-Phase 500 mg (Tablet)
Unit Price: ৳ 4.00 (30's pack: ৳ 120.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Edruc limited |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Effective in overweight patients
- Can be used as monotherapy or in combination with other oral antidiabetic agents or insulin
- Shown to reduce diabetic complications
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Immediate release and extended release tablet options
- Dosage increments for adults and children
- Special dosage considerations for renal impaired patients
Interaction
- Potential interaction with Furosemide and Nifedipine
- Potential competition with cationic drugs for renal tubular transport systems
- Drugs that may produce hyperglycemia and affect glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions affecting renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Excretion into human breast milk
- Recommendation to use insulin during pregnancy
- Caution advised for breastfeeding mothers
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia with insulin use
- Monitoring of renal function
- Caution in conditions causing dehydration or serious infections
- Annual estimation of Vitamin B12 levels
- Potential interaction with other medications
- Dose adjustment during cimetidine therapy
- Potential interaction with anticoagulants
Use in Special Populations
- Dosage adjustment in elderly subjects based on renal function
- No effect on growth and puberty detected in controlled clinical studies
- Recommendation for careful follow-up in metformin-treated children
- Particular caution recommended for children aged between 10 and 12 years
- Regular assessment of renal function
Overdose Effects
- Hypoglycemia not observed at high doses
- Occurrence of lactic acidosis
- Recommendation for hospital treatment in case of lactic acidosis
- Effectiveness of hemodialysis in removing lactate and metformin
Therapeutic Class
- Belongs to the class of Biguanides
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of reach of children