Sharpkil Plus (125 mg+31.25 mg)/5 ml (Powder for Suspension)

70 ml bottle: ৳ 265.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company One pharma ltd
Also available as
Sharpkil plus 250 mg tablet Sharpkil plus 500 mg tablet

Title

  • Sharpkil Plus 125 Syrup

Categories

  • Medicine
  • Antibiotic
  • Cephalosporin
  • Beta-lactamase Inhibitor

Description

  • Bactericidal action against sensitive bacteria
  • Interferes with bacterial cell wall synthesis
  • Active against Gram-positive and Gram-negative organisms
  • Treats infections such as pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhea, pneumonia, and typhoid fever
  • Indicated for adults and pediatric patients
  • Has minimal side effects and well-tolerated
  • Safe for use during pregnancy and breastfeeding
  • Requires careful administration with potent diuretics
  • Interacts with probenecid and drugs that reduce gastric acidity
  • Store in a cool, dry place away from light and moisture

Color Options

  • Clear

Dosage Form

  • Syrup

Dosage Strength

  • 125 mg per 5 mL

Dosage Instructions

  • Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days (adolescents and adults)
  • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days (adolescents and adults)
  • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days (adolescents and adults)
  • Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days (adolescents and adults)
  • Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days (adolescents and adults)
  • Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days (adolescents and adults)
  • Uncomplicated Gonorrhea: 1000 mg b.i.d. Single dose (adolescents and adults)
  • Community-acquired pneumonia: 250-500 mg b.i.d. for 5-10 days (adolescents and adults)
  • MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days (adolescents and adults)
  • Early Lyme disease: 500 mg b.i.d. for 20 days (adolescents and adults)
  • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days (pediatric patients)
  • Acute otitis media: 30 mg/kg/day b.i.d for 10 days (pediatric patients)
  • Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days (pediatric patients)
  • Impetigo: 30 mg/kg/day b.i.d for 10 days (pediatric patients)

Pharmacological Action

  • Bactericidal
  • Interference with bacterial cell wall synthesis
  • Beta-lactamase inhibition

Usability Features

  • Minimal side effects
  • Well-tolerated
  • Safe for use in pregnancy and breastfeeding
  • Careful administration with diuretics

Technical Specifications

  • Active against a wide range of susceptible organisms
  • Inhibits transpeptidation process
  • Protection from degradation by beta-lactamase enzymes

Material

  • Cefuroxime
  • Clavulanic Acid

Medical Class

  • Second generation Cephalosporins

Recommended Age

  • Pediatric Patients (3 months to 12 years)
  • Adolescents and adults (13 years and older)

Interaction

  • Concomitant administration of probenecid increases serum concentration
  • Reduction of gastric acidity lowers bioavailability
  • Potential cancellation of postprandial absorption effect

Contraindications

  • Known allergy to cephalosporin
  • Pseudomembranous Colitis

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Overgrowth of nonsusceptible microorganisms
  • Renal dysfunction
  • Anaphylaxis
  • Angioedema
  • Pruritus
  • Rash
  • Urticaria

Pregnancy & Lactation

  • Safe for use in later pregnancy
  • Excreted into breast milk in small quantities
  • Possibility of sensitizing the infant

Precautions & Warnings

  • Administer with care to patients on concurrent potent diuretics
  • History of colitis

Storage Conditions

  • Cool, dry place (below 30°C)
  • Away from light and moisture
  • Keep out of reach of children

FAQs

  • Indication for the treatment of infections caused by sensitive bacteria
  • Use in the treatment of pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhea, pneumonia, and typhoid fever
  • Quick onset of action within 2-3 hours
  • Duration of effect lasting 4-8 hours
  • Unknown interaction with alcohol
  • Non-habit forming medicine
  • Safe usage during pregnancy and breastfeeding
  • Prescribed for bacterial infections, even in cases of resistance

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