Losardil 25/12.5 25 mg+12.5 mg (Tablet)

Unit Price: ৳ 5.05 (4 x 14: ৳ 282.80)
Strip Price: ৳ 70.70

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Drug international ltd
Also available as
Losardil 50125 50 mg tablet Losardil 100125 100 mg tablet Losardil 10025 100 mg tablet

Indications

  • Treatment of hypertension
  • Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Affects renal tubular mechanisms of electrolyte reabsorption

Dosage

  • Usual starting dose of 50/12.5 is one tablet once daily
  • Maximum dose is 100/25 once daily
  • Antihypertensive effect is attained within three weeks after initiation of therapy

Administration

  • May be administered with other antihypertensive agents
  • Can be taken with or without food

Interaction

  • No significant drug-drug interactions found in studies with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine, and Phenobarbital
  • Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase serum potassium

Contraindications

  • Contraindicated in patients hypersensitive to any component of the product
  • Contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension including dizziness may occur
  • Hyperkalaemia occurs occasionally
  • Angioedema has been reported with some angiotensin-II receptor antagonists

Pregnancy & Lactation

  • Avoided in pregnancy unless essential
  • Not recommended in breastfeeding
  • Limited information on use during breastfeeding

Precautions & Warnings

  • Periodic determination of serum electrolytes to detect possible imbalance should be performed
  • Hypokalemia may rarely develop, especially with brisk diuresis

Use in Special Populations

  • Usual therapy regimens may be followed as long as the patient's creatinine clearance is >30 ml/min
  • Loop diuretics preferred to thiazides in patients with severe renal impairment
  • Not recommended for titration in patients with hepatic impairment

Overdose Effects

  • Manifestations of overdosage may include hypotension, tachycardia, and electrolyte depletion

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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