Candiver 50 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Veritas pharmaceuticals ltd |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes responsible for the synthesis of ergosterol.
Dosage & Administration
- Adults:
- Vaginal Candidiasis: 150 mg as a single dose
- Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
- Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
- Kerion: 50 mg daily for 20 days
- Pityriasis versicolor: 400 mg as a single dose
- Onychomycosis: 150 mg weekly for 12 months
- Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
- Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
- Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
- Children over 1 year:
- In Superficial Candidiasis: 1-2 mg/kg daily
- In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
- Use in Specific Population: Elderly patient: The normal dose should be used if there is no evidence of renal impairment. Renal Impairment: No adjustment in single dose therapy is required. In multiple dose therapy of patients with renal impairment, normal doses should be given on days 1 and 2 of treatment
Interaction
Fluconazole can interact with medications like warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptives, cyclosporin, theophylline, cimetidine, antacids, and food.
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds.
Side Effects
- Nausea
- Abdominal discomfort
- Diarrhoea
- Fatulence
- Rash
- Anaphylaxis
Pregnancy & Lactation
Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. Accordingly, it should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.
Precautions & Warnings
Abnormalities of hepatic, renal, haematological and other biochemical function tests have been observed. Patients have rarely developed exfoliative cutaneous reactions. Fuconazole is found in human breast milk at concentrations similar to plasma, hence its use in nursing mothers is not recommended.
Use in Special Populations
- Elderly: The normal dose should be used if there is no evidence of renal impairment
- Renal impairment: No adjustments in single dose therapy are required. In multiple dose therapy of patients with renal impairment, normal dose should be given on days 1 and 2 of treatment.
Overdose Effects
Supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis would probably increase the elimination rate.
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.