Ceftrimax 1 gm/vial (IV Injection)

1 gm vial: ৳ 190.57

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Veritas pharmaceuticals ltd
Also available as
Ceftrimax 500 mg injection Ceftrimax 1 gm injection Ceftrimax 2 gm injection Ceftrimax 500 mg injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with bacterial cell wall synthesis
  • High stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Excreted unchanged in the urine
  • Highly protein bound (95%)

Dosage

  • Usual dose for adults: 1 to 2 gm intravenous or intramuscular administration once a day
  • Maximum dose for adults: 4 gm/day
  • Usual dose for uncomplicated gonococcal infections in adults: 250 mg intramuscular as a single dose
  • Usual dose for surgical prophylaxis in adults: 1 g intravenous as a single dose
  • Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for infants and children: 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections
  • Intramuscular injection solution: 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1%
  • Intravenous injection solution: 250 mg or 500 mg Ceftriaxone dissolved in Water for injection

Interaction

  • No reported drug interactions

Contraindications

  • Hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, and vomiting
  • Cutaneous reactions including rash, pruritus, and urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia, and anemia
  • Hepatic reactions including elevations of SGOT or SGPT
  • CNS reactions including nervousness, confusion, and headache
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

  • Not established safe for human pregnancy
  • Caution advised during lactation

Precautions & Warnings

  • Risk of anaphylactic shock
  • Potential presence of gallbladder sludge
  • Requirement for regular blood picture checks during prolonged treatment

Use in Special Populations

  • Must not be given to neonates if premature or newborn (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light & moisture
  • Keep out of the reach of children

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