Ceftrimax 500 mg/vial (IV Injection)

500 mg vial: ৳ 130.39

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Veritas pharmaceuticals ltd
Also available as
Ceftrimax 500 mg injection Ceftrimax 1 gm injection Ceftrimax 1 gm injection Ceftrimax 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Kills bacteria by interfering with the synthesis of the bacterial cell wall. Not metabolized in the body. Highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • Maximum dose: 4 gm/day
  • Infants and Children (01 month or older):
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day
    • Maximum dose: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days.

Administration

  • Intramuscular Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
    • 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection
  • Intravenous Injection:
    • 250 mg or 500 mg Ceftriaxone dissolved in Water for injection
    • 1 g Ceftriaxone in 10 ml of Water for injection USP
    • 2 g Ceftriaxone in 20 ml of Water for injection
  • Injection Administration: Administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL.

Interaction

No drug interactions reported.

Contraindications

Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics.

Side Effects

  • Gastrointestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Rare occurrence of local phlebitis following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established. Low concentrations excreted in human milk. Caution in lactating mothers.

Precautions & Warnings

  • Anaphylactic shock possible, requires immediate countermeasures
  • Rare cases of gallbladder sludge detected by sonograms
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

Must not be given to premature and newborn neonates (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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