Losardil 100/25 100 mg+25 mg (Tablet)

Unit Price: ৳ 12.05 (2 x 10: ৳ 241.00)
Strip Price: ৳ 120.50

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Drug international ltd
Also available as
Losardil 25125 25 mg tablet Losardil 50125 50 mg tablet Losardil 100125 100 mg tablet

Indications

  • Treatment of hypertension
  • Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Potent vasoconstrictor
  • Primary vasoactive hormone of the renin-angiotensin system
  • Stimulates aldosterone secretion
  • Selective blocking of angiotensin II
  • Thiazide diuretic effect
  • Increased excretion of Sodium and Chloride
  • Reduction of plasma volume
  • Increase in plasma renin activity
  • Increase in Aldosterone secretion
  • Increase in urinary Potassium loss
  • Decrease in serum Potassium
  • Mediated by angiotensin II
  • Reversible, competitive inhibitor of the AT1 receptor

Dosage

  • Usual starting dose of 50/12.5 is one tablet once daily
  • Maximum dose of 100/25 once daily
  • Initial dose for severe hypertension is one tablet of 50/12.5 once daily
  • Initial treatment of severe hypertension is one tablet of 50/12.5 once daily
  • No initial dosage adjustment of 50/12.5 is necessary for elderly patients

Administration

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Interaction

  • No significant drug-drug pharmacokinetic interactions found with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine, and Phenobarbital
  • Potential interaction with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium
  • Possible interaction with non-steroidal anti-inflammatory drug Indomethacin
  • Interaction with alcohol, barbiturates, or narcotics-potentiation of orthostatic hypotension may occur
  • Dosage adjustment of the antidiabetic drug may be required with concurrent use
  • Additive effect or potentiation with other antihypertensive drugs
  • Impaired absorption in the presence of anionic exchange resins

Contraindications

  • Hypersensitivity to any component of the product
  • Anuria or hypersensitivity to other sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension including dizziness
  • Hyperkalaemia
  • Angioedema
  • Vertigo
  • Gastro-intestinal disturbances
  • Angina
  • Palpitation
  • Oedema
  • Dyspnoea
  • Headache
  • Sleep disorders
  • Malaise
  • Urticaria
  • Pruritus
  • Rash
  • Hepatitis
  • Atrial fibrillation
  • Cerebrovascular accident
  • Syncope
  • Pancreatitis
  • Anaphylaxis
  • Cough
  • Depression
  • Erectile dysfunction
  • Anaemia
  • Thrombocytopenia
  • Hyponatraemia
  • Arthralgia
  • Myalgia
  • Renal impairment
  • Rhabdomyolysis
  • Tinnitus
  • Photosensitivity
  • Vasculitis

Pregnancy & Lactation

  • Avoided in pregnancy unless essential
  • Adversely affect fetal and neonatal blood pressure control and renal function
  • Skull defects and oligohydramnios reported
  • Not recommended in breastfeeding
  • Alternative treatment options available with better-established safety information during breastfeeding

Precautions & Warnings

  • Hypersensitivity: Angiooedema
  • Periodic determination of serum electrolytes
  • Hypokalemia risk
  • Impaired renal function
  • Symptomatic hypotension

Use in Special Populations

  • Use in Patients with Renal Impairment
  • Use in Patients with Hepatic Impairment
  • Use in pediatric patients

Overdose Effects

  • Manifestations of overdosage including hypotension, tachycardia, and bradycardia
  • Supportive treatment for symptomatic hypotension
  • Potential electrolyte depletion and dehydration from excessive diuresis
  • Possible accentuation of cardiac arrhythmias if digitalis has been administered
  • Removal by hemodialysis not established

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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