Atracurium Hameln 25 mg/2.5 ml (IV Injection)
2.5 ml ampoule: ৳ 242.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atracurium besilate |
| Company | Siegfried hameln germany |
Indications
- Endotracheal intubation
- Mechanical ventilation
- Muscle relaxant in general anaesthesia
Pharmacology
- Antagonizes acetylcholine neurotransmitter action
- Binds competitively with cholinergic receptor sites
- Inhibited by acetylcholinesterase inhibitors
Dosage & Administration
- Initial dose of 300-600 mcg/kg as bolus IV
- Subsequent doses every 15-25 min
- Infusion rate for prolonged procedures
Interaction
- Enhanced neuromuscular blocking effect with general anaesthetics
- Enhanced effect with certain antibiotics
- Interactions with lithium, magnesium salts, procainamide, quinidine
Contraindications
- Hypersensitivity to atracurium, cisatracurium, benzenesulfonic acid
- Paralysis of respiratory and skeletal muscles
Side Effects
- Skin flush
- Erythema
- Pruritus
- Urticaria
- Wheezing
- Increased bronchial secretions
- Bronchospasm
- Angioedema
- CV effects
- Anaphylaxis potential
Pregnancy & Lactation
- Pregnancy Category C
- Potential teratogenic effects in animals
- Limited studies in pregnant women
- Benefit justifying potential risk
Precautions & Warnings
- Patients with CV disease, burn injury, asthma
- Conditions antagonizing neuromuscular blockade
- Conditions potentiating neuromuscular blockade
- Pregnancy and lactation considerations
Overdose Effects
- Stimulation of histamine release
- CV effects especially hypotension
Therapeutic Class
- Non depolarizing muscle relaxants
Storage Conditions
- Store between 2-8°C
- Do not freeze