Tolfem 200 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Tolfenamic acid
Company Square pharmaceuticals plc

Title and Category

  • Tolfem 200 mg Tablet
  • Pain Relief
  • Analgesic
  • Anti-inflammatory
  • NSAID
  • Migraine Relief
  • Post-operative Pain Relief

Dimensions

  • N/A

Color Options

  • N/A

Functions

  • Relieves migraine headache pain
  • Acts as an analgesic for post-operative pain
  • Reduces fever

Materials

  • Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid)

Technical Specifications

  • Molecular Formula: C14H12ClNO2
  • Peak plasma concentration: 60-90 min
  • Bioavailability: 85%
  • Protein-binding: 99%
  • Plasma half-life: 2 hours
  • Metabolism: Liver metabolism
  • Excretion: Urine (90%) and feces

Design Elements

  • Chemical Structure: C14H12ClNO2
  • Chemical Structure Image: Included

Usability Features

  • Taken with food
  • Recommendation to take water during or immediately after meals

Indications

  • Relieving the pain of migraine headache
  • Recommended for use as an analgesic in post-operative pain and fever

Pharmacology

  • Potent inhibitor of cyclooxygenase enzyme
  • Inhibits synthesis of inflammatory mediators like thromboxane (TX) B2 and prostaglandin (PG) E2
  • Direct antagonistic action on prostaglandin receptors

Dosage & Administration

  • Adult dosage for acute migraine attacks: 200 mg when symptoms appear, may be repeated once after 1-2 hours
  • Adult dosage for mild to moderate pain: 100-200 mg tid
  • Dosage adjustments may be necessary for renal impairment
  • Avoid in case of severe renal impairment
  • No established pediatric dosage regimen
  • Should be taken with food
  • Water intake during or immediately after meals

Interaction

  • Increased absorption with Metoclopramide and Magnesium hydroxide
  • Decreased absorption with Aluminium hydroxide
  • Increased risk of bleeding with anticoagulants and other NSAIDs
  • Decreased antihypertensive response to loop diuretics, B-blockers, and ACE Inhibitors
  • Co-administration increases plasma concentration of Lithium, Methotrexate, and cardiac glycosides
  • Increased risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics

Contraindications

  • Active gastro-intestinal bleeding
  • Active gastro-intestinal ulceration
  • History of gastro-intestinal bleeding related to previous NSAID therapy
  • Severe heart failure

Side Effects

  • Rare side effects: alveolitis, hepatic damage, pancreatitis, pulmonary eosinophilia, Stevens-johnson syndrome
  • Other side effects: blood disorder, depression, diarrhea, dizziness, drowsiness, dysuria, euphoria, gastro-intestinal bleeding, gastro-intestinal discomfort, hallucination, insomnia, malaise, nausea, hearing disturbances, rash, visual disturbances, vertigo, raised blood pressure
  • Overdose symptoms: headache, nausea, vomiting, gastro-intestinal bleeding, drowsiness, dizziness, convulsion, acute renal failure, liver damage

Pregnancy & Lactation

  • Not recommended during pregnancy unless essential
  • Avoid during the third trimester of pregnancy
  • NSAIDs may appear in breast milk in very low concentrations, should be avoided if possible when breastfeeding

Precautions & Warnings

  • Patients with asthma bronchospasm, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, cardiac or renal function impairment, and elderly
  • Increased water intake or dose reduction to reduce dysuria

Overdose Effects

  • Symptoms: headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, excitation, coma, drowsiness, dizziness, tinnitus, fainting, convulsions, acute renal failure, liver damage
  • Symptomatic treatment required

Therapeutic Class

  • Rheumatoid Arthritis Drugs
  • NSAIDs
  • Migraine Relief Drugs

Storage Conditions

  • Store in a cool, dry place away from light
  • Keep out of the reach of children

Commonly Asked Questions

  • What is Tolfem 200 mg Tablet? - It is a potent inhibitor of cyclooxygenase enzyme, inhibiting the synthesis of important inflammatory mediators
  • What are the uses of Tolfem 200 mg Tablet? - Treatment of acute migraine attacks and mild to moderate pain
  • Quick Tips: Should be taken with food or milk, can cause serious complications if taken for a long time, can raise the risk of blood clots, heart attack, or stroke, inform doctor if pregnant or planning to conceive, inform doctor if diagnosed with kidney or liver problems

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