Losart Plus 100 mg+25 mg (Tablet)

Unit Price: ৳ 12.03 (3 x 10: ৳ 360.90)
Strip Price: ৳ 120.30

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Acme laboratories ltd
Also available as
Losart plus 50 mg tablet Losart plus 100 mg tablet

Indications

  • Treatment of hypertension
  • Risk reduction of stroke in hypertensive patients with left ventricular hypertrophy

Pharmacology

  • Losartan blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Hydrochlorothiazide affects renal tubular mechanisms of electrolyte reabsorption

Dosage

  • Usual starting dose of 50/12.5 is one tablet once daily
  • Usual antihypertensive effect is attained within three weeks after initiation of therapy

Administration

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Interactions

  • No significant drug-drug interactions with Losartan Potassium
  • Thiazide diuretics may interact with alcohol, barbiturates, or narcotics
  • Dosage adjustment of antidiabetic drugs may be required

Contraindications

  • Contraindicated in patients hypersensitive to any component of the product
  • Contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension including dizziness
  • Occasional hyperkalaemia
  • Reported cases of angioedema and vertigo

Pregnancy & Lactation

  • Avoided in pregnancy unless essential
  • Not recommended in breastfeeding

Precautions & Warnings

  • Periodic determination of serum electrolytes recommended
  • Hypokalemia may rarely develop, especially with brisk diuresis

Use in Special Populations

  • Use with caution in patients with renal impairment
  • Not recommended for titration in patients with hepatic impairment

Overdose Effects

  • Manifestations may include hypotension, tachycardia, and bradycardia
  • Supportive treatment recommended in cases of symptomatic hypotension

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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