Losatan HZ 50 mg+12.5 mg (Tablet)

Indications

• Treatment of hypertension
• Risk reduction of stroke in hypertensive patients with left ventricular hypertrophy

Pharmacology

• Block vasoconstrictor and aldosterone-secreting effects of angiotensin II
• Selective binding blockade of angiotensin II to the AT1 receptor
• Thiazide diuretic effect on renal tubular mechanisms of electrolyte reabsorption
• Increase in excretion of Sodium and Chloride
• Reduction in plasma volume and increase in plasma renin activity

Dosage

• Usual starting dose of 50/12.5 is one tablet once daily
• Maximum dose is 100/25 once daily
• Antihypertensive effect is attained within three weeks after initiation of therapy

Administration

• May be administered with or without food
• May be administered with other antihypertensive agents

Interaction

• No significant drug-drug interactions found in interaction studies with various drugs
• Concomitant use of potassium-sparing diuretics may lead to increase in serum potassium
• Potential interaction with alcohol, barbiturates, narcotics, and antidiabetic drugs

Contraindications

• Contraindicated in patients hypersensitive to any component of the product
• Contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

• Symptomatic hypotension including dizziness
• Occasional hyperkalaemia
• Reports of angioedema, vertigo, gastro-intestinal disturbances, and headache
• Rare reports of hepatits, atrial fibrillation, and renal impairment

Pregnancy & Lactation

• Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential
• Limited information on the use of angiotensin-II receptor antagonists in breastfeeding

Precautions & Warnings

• Periodic determination of serum electrolytes
• Rare development of hypokalemia
• Caution in patients with impaired renal function and symptomatic hypotension

Use in Special Populations

• Use caution with renal impairment
• Not recommended for titration in patients with hepatic impairment
• Safety and effectiveness in pediatric patients not established

Overdose Effects

• Manifestations of hypotension and tachycardia in overdosage
• Supportive treatment should be instituted in case of symptomatic hypotension
• Limited data available on overdosage in humans

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Do not store above 30°C
• Keep out of the reach of children

Related Brands

• Losium Plus 50 mg+12.5 mg (Tablet) - ibn-sina-pharmaceuticals-ltd
• Lospil Plus 50 mg+12.5 mg (Tablet) - the-white-horse-pharmaceuticals-ltd
• Osartan-HZ 50 mg+12.5 mg (Tablet) - aristopharma-ltd
• Osartil Plus 50 mg+12.5 mg (Tablet) - incepta-pharmaceuticals-ltd
• Osartil Plus 100 mg+12.5 mg (Tablet) - incepta-pharmaceuticals-ltd