Osartil Plus 100 mg+12.5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium hydrochlorothiazide |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy
Pharmacology
- Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II
- Hydrochlorothiazide affects renal tubular mechanisms of electrolyte reabsorption
Dosage
- Usual starting dose of 50/12.5 is one tablet once daily
- Maximum dose is 100/25 once daily
- Antihypertensive effect attained within three weeks after initiation of therapy
Administration
- May be administered with or without food
- Can be administered with other antihypertensive agents
Interaction
- Concomitant use of potassium-sparing diuretics may lead to increase in serum potassium
- Thiazide diuretics may interact with alcohol, barbiturates, or narcotics
- Dosage adjustment of antidiabetic drugs may be required
Contraindications
- Hypersensitivity to any component of the product
- Anuria or hypersensitivity to other sulfonamide-derived drugs
Side Effects
- Symptomatic hypotension including dizziness
- Hyperkalaemia
- Angioedema
- Vertigo
- Gastro-intestinal disturbances
- Headache
- Pruritus
- Hepatitis
- Cough
- Depression
- Anemia
- Renal impairment
Pregnancy & Lactation
- Avoided in pregnancy unless essential
- Not recommended in breastfeeding
Precautions & Warnings
- Periodic determination of serum electrolytes
- Hypokalemia may rarely develop
- Impaired renal function
- Symptomatic hypotension
Use in Special Populations
- Loop diuretics preferred in patients with severe renal impairment
- Not recommended for titration in patients with hepatic impairment
- Safety and effectiveness in pediatric patients have not been established
Overdose Effects
- Manifestation of overdosage would be hypotension and tachycardia
- Supportive treatment should be instituted for symptomatic hypotension
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Do not store above 30°C
- Keep out of the reach of children