Oscard 50 mg+12.5 mg (Tablet)
Unit Price: ৳ 6.01 (3 x 10: ৳ 180.31)
Strip Price: ৳ 60.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium hydrochlorothiazide |
| Company | Sharif pharmaceuticals ltd |
Indications
- Treatment of hypertension
- Reduce risk of stroke in patients with hypertension and left ventricular hypertrophy
Pharmacology
- Angiotensin II vasoconstrictor
- Renin-angiotensin system
- Aldosterone secretion
- Selective AT1 receptor blocker
- Thiazide diuretic effect
- Renal tubular electrolyte reabsorption
- Plasma volume reduction
- Increases in plasma renin activity
- Increases in aldosterone secretion
- Increases in urinary potassium loss
- ACE inhibitor
- Cardiovascular regulation
Dosage
- Usual starting dose
- Dosage adjustment for elderly patients
- Severe hypertension treatment
- Antihypertensive effect timeline
- Initial dose for severe hypertension
Administration
- May be administered with other antihypertensive agents
- May be administered with or without food
Interaction
- Drug-drug pharmacokinetic interactions
- Potassium-sparing diuretics
- Non-steroidal anti-inflammatory drug interaction
- Thiazide diuretic interactions
- Antidiabetic drug interactions
- Other antihypertensive drug interactions
- Cholestyramine and colestipol resins interaction
Contraindications
- Hypersensitivity to any component
- Anuria
- Hypersensitivity to sulfonamide-derived drugs
Side Effects
- Symptomatic hypotension
- Hyperkalaemia
- Angioedema
- Vertigo
- Gastro-intestinal disturbances
- Angina
- Palpitation
- Oedema
- Dyspnoea
- Headache
- Sleep disorders
- Malaise
- Urticaria
- Pruritus
- Rash
- Hepatitis
- Atrial fibrillation
- Cerebrovascular accident
- Syncope
- Paraesthesia
- Pancreatitis
- Anaphylaxis
- Cough
- Depression
- Erectile dysfunction
- Anaemia
- Thrombocytopenia
- Hyponatraemia
- Arthralgia
- Myalgia
- Renal impairment
- Rhabdomyolysis
- Tinnitus
- Photosensitivity
- Vasculitis
Pregnancy & Lactation
- Avoid in pregnancy
- Adverse effects on fetal and neonatal blood pressure control and renal function
- Skull defects and oligohy dramnios
- Not recommended in breastfeeding
Precautions & Warnings
- Hypersensitivity precautions
- Serum electrolytes determination
- Hypokalemia precautions
- Impaired renal function precautions
- Symptomatic hypotension precautions
Use in Special Populations
- Renal impairment regimens
- Hepatic impairment precautions
- Pediatric safety and effectiveness
Overdose Effects
- Manifestation of overdosage
- Supportive treatment for symptomatic hypotension
- Ineffectiveness of hemodialysis for losartan removal
- Electrolyte depletion signs and symptoms
- Emphasized cardiac arrhythmias precautions
- Ineffectiveness of hemodialysis for hydrochlorothiazide removal
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Do not store above 30°C
- Keep out of the reach of children