Ostan Plus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Renata limited
Also available as
Ostan plus 100 mg tablet

Indications

  • Treatment of hypertension
  • Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Blockage of angiotensin II binding to the AT1 receptor
  • Inhibition of aldosterone secretion
  • Effect on renin-angiotensin system
  • Action as a thiazide diuretic
  • Affect on renal tubular mechanisms of electrolyte reabsorption

Dosage

  • Usual starting dose
  • Dose adjustments based on individual response
  • Anticipated antihypertensive effect timeframe
  • Special considerations for severe hypertension
  • No initial dosage adjustment for elderly patients

Administration

  • May be administered with other antihypertensive agents
  • Can be taken with or without food

Interaction

  • Drug-drug interaction studies with various medications
  • Potential interactions with potassium-sparing diuretics and potassium supplements
  • Interaction with antidiabetic drugs
  • Potential additive effect or potentiation with other antihypertensive drugs
  • Impairment of Hydrochlorothiazide absorption in the presence of anionic exchange resins

Contraindications

  • Hypersensitivity to any component of the product
  • Anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension and dizziness
  • Occasional occurrence of hyperkalaemia
  • Reported cases of angioedema
  • Less common effects such as vertigo, gastro-intestinal disturbances, angina, palpitation, oedema, dyspnoea, headache, and more

Pregnancy & Lactation

  • Avoidance of use in pregnancy unless essential
  • Limited information on use in breastfeeding
  • Recommendation for alternative treatment options during breastfeeding

Precautions & Warnings

  • Hypersensitivity and angioedema
  • Periodic determination of serum electrolytes
  • Risk of hypokalemia in certain conditions
  • Impaired renal function and symptomatic hypotension

Use in Special Populations

  • Use in Patients with Renal Impairment and recommendations for creatinine clearance levels
  • Recommendations regarding hepatic impairment
  • Absence of established safety and effectiveness in pediatric patients

Overdose Effects

  • Potential manifestations and supportive treatment for overdosage
  • Absence of hemodialysis removal for losartan and its metabolite

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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