Parten Plus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 6.04 (3 x 10: ৳ 181.20)
Strip Price: ৳ 60.40

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Jayson pharmaceuticals ltd

Indications

  • Treatment of hypertension
  • Reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Primary vasoactive hormone of the renin-angiotensin system
  • Potent vasoconstrictor
  • Stimulates aldosterone secretion
  • Selective blocker of AT1 receptor
  • Inhibits ACE
  • Thiazide diuretic
  • Affects renal tubular mechanisms of electrolyte reabsorption
  • Reduces plasma volume
  • Increases plasma renin activity
  • Increases aldosterone secretion
  • Increases urinary potassium loss
  • Decreases serum potassium

Dosage

  • Usual starting dose of 50/12.5 is one tablet once daily
  • Maximum dose is 100/25 once daily
  • Antihypertensive effect attained within three weeks after initiation of therapy
  • No initial dosage adjustment necessary for elderly patients

Administration

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Interaction

  • No significant drug-drug pharmacokinetic interactions found in interaction studies with various drugs
  • Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may lead to increase in serum potassium
  • Potential interactions with alcohol, barbiturates, narcotics, antidiabetic drugs, other antihypertensive drugs, cholestyramine, and colestipol resins

Contraindications

  • Hypersensitivity to any component of the product
  • Anuria
  • Hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension including dizziness
  • Hyperkalaemia
  • Angioedema
  • Vertigo
  • Gastro-intestinal disturbances
  • Angina
  • Palpitation
  • Oedema
  • Dyspnoea
  • Headache
  • Sleep disorders
  • Malaise
  • Urticaria
  • Pruritus
  • Rash
  • Hepatitis
  • Atrial fibrillation
  • Cerebrovascular accident
  • Syncope
  • Paraesthesia
  • Pancreatitis
  • Anaphylaxis
  • Cough
  • Depression
  • Erectile dysfunction
  • Anaemia
  • Thrombocytopenia
  • Hyponatraemia
  • Arthralgia
  • Myalgia
  • Renal impairment
  • Rhabdomyolysis
  • Tinnitus
  • Photosensitivity
  • Vasculitis

Pregnancy & Lactation

  • Avoided in pregnancy unless essential
  • Adversely affect fetal and neonatal blood pressure control and renal function
  • Not recommended in breastfeeding

Precautions & Warnings

  • Periodic determination of serum electrolytes
  • Hypokalemia
  • Impaired renal function
  • Use in Patients with Renal Impairment
  • Use in Patients with Hepatic Impairment
  • Use in pediatric patients
  • Not recommended for titration in patients with hepatic impairment

Use in Special Populations

  • Usual regimens of therapy with 50/12.5 may be followed with creatinine clearance >30 ml/min
  • Loop diuretics preferred to thiazides in more severe renal impairment
  • Safety and effectiveness in pediatric patients not established

Overdose Effects

  • Manifestations of hypotension, tachycardia, bradycardia
  • Supportive treatment for symptomatic hypotension
  • Limited data available in regard to overdosage in humans
  • Signs and symptoms caused by electrolyte depletion

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

Related Brands