Prazia 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Amico laboratories ltd
Also available as
Prazia 40 mg capsule

Title

Prazia 20 mg Capsule

Categories

  • Medicine
  • Health
  • Pharmaceutical

Description

Prazia 20 mg Capsule is a proton pump inhibitor used to relieve chronic heartburn, heal erosive esophagitis, eradicate H. pylori infection, and treat Zollinger-Ellison Syndrome, dyspepsia, duodenal and gastric ulcers.

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Management of duodenal & gastric ulcers

Pharmacology

  • ModeOfAction: Proton pump inhibitor suppressing gastric acid secretion
  • Absorption: Enteric-coated pellet formulation with peak plasma levels at ~1.5 hours
  • Distribution: 97% plasma protein binding, steady state volume of distribution ~16 L
  • Metabolism: Extensively metabolized in the liver by CYP enzymes
  • Excretion: Plasma elimination half-life of ~1-1.5 hours, <1% excreted in urine

Dosage

  • Oral:
    • Adults:
      • HealingOfErosiveEsophagitis:
        • 20 mg or 40 mg once daily for 4-8 weeks
      • MaintenanceOfHealing:
        • 20 mg once daily
      • SymptomaticGERD:
        • 20 mg once daily for 4 weeks
      • HelicobacterPyloriEradication:
        • Esomeprazole 40 mg once daily for 10 days, Amoxicillin 1000 mg twice daily, Clarithromycin 500 mg twice daily for 10 days
      • ZollingerEllisonSyndrome:
        • 20-80 mg once daily
      • AcidRelatedDyspepsia:
        • 20-40 mg once daily for 2-4 weeks
      • DuodenalUlcer:
        • 20 mg once daily for 2-4 weeks
      • GastricUlcer:
        • 20-40 mg once daily for 4-8 weeks
    • PediatricPatients:
      • GERDWithErosiveEsophagitis:
        • 10 mg or 20 mg once daily based on body weight
      • RiskReductionOfRebleeding:
        • 80 mg IV infusion over 30 minutes
  • IVInjection:
    • AdultPatients:
      • 20 mg or 40 mg once daily, IV Injection: >3 Minutes, IV Infusion: 10-30 minutes
    • PediatricPatients:
      • 10-20 mg once daily based on body weight, IV Infusion: 10-30 minutes

Administration

  • TabletOrCapsule:
    • Swallowed whole, taken one hour before a meal
  • OralSuspension:
    • Mixed with water and taken immediately, administered through a tube within 30 minutes
  • IVInjection:
    • Prepared with 0.9% Sodium Chloride, administered over at least 3 minutes

Interaction

  • MetabolismInhibition: Potential interference with CYP2C19, gastric pH-based absorption
  • NoClinicalInteractionsWith:
    • Phenytoin, warfarin, quinidine, clarithromycin, amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

SideEffects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

PregnancyAndLactation

No adequate and well-controlled studies in pregnant women, excretion in milk not studied, breastfeeding not recommended if essential

PrecautionsAndWarnings

  • GastricMalignancy: Symptomatic response does not rule out presence of malignancy
  • AdministrationTip: Prazia capsules should be taken at least one hour before meals, can be opened and mixed with applesauce if swallowing is difficult, antacids may be used alongside

UseInSpecialPopulations

  • PediatricUse: Safety and effectiveness not established
  • GeriatricUse: No overall differences observed in safety and efficacy, greater sensitivity in some older individuals
  • HepaticInsufficiency: No dosage adjustment for mild to moderate insufficiency, limited to 20 mg once daily in severe insufficiency
  • RenalInsufficiency: Pharmacokinetics not expected to be altered

OverdoseEffects

  • ToxicityInRats: Lethal at 510 mg/kg, acute signs include reduced motor activity, respiratory changes, tremor, and convulsions
  • Management: Symptomatic and supportive treatment, not expected to be removed by dialysis

StorageConditions

Store at a temperature not exceeding 30°C, protect from light and moisture, keep out of reach of children

ChemicalStructure

  • MolecularFormula: C17H19N3O3S
  • ImageURL: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

CommonQuestions

  • WhatIsIt: Proton pump inhibitor for reducing stomach acid
  • Uses: Treats GERD, ulcers, and conditions with excess stomach acid
  • SideEffects: May include headaches, diarrhea, nausea, and other gastrointestinal symptoms
  • PregnancyAndBreastfeeding: Consult doctor for risks and benefits
  • OnsetOfAction: Usually within a few hours

Related Brands