Capcitab 500 mg (Tablet)

Unit Price: ৳ 125.00 (7 x 4: ৳ 3,500.00)

Strip Price: ৳ 500.00

Medicine Details

Category	Details
Generic	Capecitabine
Company	Eskayef pharmaceuticals ltd
Also available as	Capcitab 150 mg tablet

Therapeutic Class

Cytotoxic Chemotherapy

Indications

Adjuvant Colon Cancer
Metastatic Colorectal Cancer
Metastatic Breast Cancer

Mode of Action

Nucleoside Metabolic Inhibitor
Antineoplastic Activity
Selective Tumour-Activated Prodrug

Dosage & Administration

1250 mg/m2 twice daily orally for 2 weeks followed by a one-week rest period in 3-week cycles
Monotherapy
Adjuvant treatment for a total of 6 months (8 cycles)
In combination with docetaxel at recommended doses
Individualized dosage based on body surface area

Interaction

Anticoagulants monitoring
Phenytoin level monitoring
Leucovorin interaction
CYP2C9 substrates co-administration
Effect of food on absorption

Contraindications

Severe Renal Impairment
Hypersensitivity
Leucopenia, Neutropenia or Thrombocytopenia
Severe reactions to fluoropyrimidine therapy
Complete DPD deficiency
Pregnancy or breast-feeding

Side Effects

Abdominal pain
Rash
Dry or itchy skin
Tiredness
Loss of appetite
Diarrhea
Vomiting
Nausea
Stomatitis
Hand-and-foot skin-reaction
Fever
Infection
Chest pain
Steven-Johnson syndrome

Pregnancy & Lactation

Pregnancy category D
Potential fetal harm
Capecitabine excretion in breast milk

Precautions & Warnings

Coagulopathy monitoring
Diarrhea management
Cardiotoxicity in patients with history of coronary artery disease
Risk of severe adverse reactions in patients with low or absent DPD activity
Dehydration and Renal Failure risk
Mucocutaneous and Dermatologic Toxicity
Hyperbilirubinemia monitoring
Hematologic parameters monitoring

Overdose Effects

Nausea
Vomiting
Diarrhea
Mucositis
Gastrointestinal irritation and bleeding
Bone marrow depression

Storage Conditions

Keep in a dry place
Store below 30°C
Protect from light
Keep out of the reach of children

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