Carbotor 10 mg/ml (IV Infusion)
150 mg vial: ৳ 1,600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carboplatin |
| Company | Eskayef pharmaceuticals ltd |
Indications
- Treatment of advanced ovarian carcinoma of epithelial origin
- Palliative treatment of recurrent ovarian carcinoma
Pharmacology
- Alkylating agent
- Binds covalently to DNA
- Modifies cell cycle
Dosage & Administration
- Intravenous use only
- Recommended dosage of 400 mg/m2
- Dosage adjustment for renal impairment
- Nadir determination for dosage adjustment
Interaction
- Not to be mixed with other drugs
- Potentiation of renal effects by neurotoxic compounds
Contraindications
- Severe renal impairment
- Severe myelosuppression
- History of severe allergic reactions
- Bleeding tumors
Side Effects
- Bone marrow suppression
- Thrombocytopenia
- Neutropenia
- Leucopenia
- Anaemia
- Infectious and hemorrhagic complications
- Nephrotoxicity
- Elevation of serum creatinine and blood urea nitrogen
- Gastrointestinal toxicity
- Nausea and vomiting
- Diarrhea and constipation
- Allergic reactions
- Hepatic toxicity
- Neurotoxicity
- Peripheral and central nervous symptoms
Pregnancy & Lactation
- Pregnancy Category D
- Excretion in human milk
Precautions & Warnings
- Administered under supervision of qualified physician
- Monitoring of blood counts and renal/hepatic function
- Discontinuation in case of abnormal marrow or renal/hepatic function
- Closely related myelosuppression and renal clearance
- Frequent monitoring of peripheral blood counts
- Careful planning of combination therapy
- Supportive transfusional therapy for myelosuppression
- Premedication with antiemetics to reduce nausea/vomiting
- Careful use with nephrotoxic compounds
- Management of allergic reactions
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store below 25°C
- Dry place, do not refrigerate
- Keep out of reach of children