Docetor 20 mg/vial (IV Infusion)

20 mg vial: ৳ 4,000.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Eskayef pharmaceuticals ltd
Also available as
Docetor 80 mg injection

Product Title

  • Docetor

Categories

  • Antineoplastic Agent
  • Chemotherapy Medication
  • Cytotoxic Chemotherapy

Description

  • Docetor is a microtubule inhibitor indicated for various types of cancers such as Breast Cancer (BC), Non-small Cell Lung Cancer (NSCLC), Castration-Resistant Prostate Cancer (CRPC), Gastric Adenocarcinoma (GC), and Squamous Cell Carcinoma of the Head and Neck (SCCHN). It is administered intravenously and is contraindicated in certain medical conditions.

Color Options

  • N/A

Function

  • Disrupts microtubular network in cells
  • Promotes assembly of tubulin into stable microtubules
  • Inhibits disassembly of microtubules
  • Decreases intracellular concentration of tubulin
  • Inhibits mitosis in cells

Dosage & Administration

  • Administered intravenously over 1 hr
  • Dosage varies for different types of cancer (e.g., BC, NSCLC, HRPC, GC, SCCHN)
  • Premedicate with oral corticosteroids
  • Adjust dose as needed

Mode of Action

  • Disruption of microtubular network in cells essential for vital cellular functions

Interaction

  • Docetor is a CYP3A4 substrate, and its metabolism may be modified by other compounds that interact with CYP3A4

Contraindications

  • Neutrophil counts of <1500 cells/mm^3
  • Severe hypersensitivity reactions to docetaxel or polysorbate 80

Side Effects

  • Common adverse reactions include infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin reactions, and myalgia

Pregnancy & Lactation

  • Can cause fetal harm when administered to a pregnant woman
  • No information available on its presence in human milk or its effects on breastfeeding

Precautions & Warnings

  • Should be administered under the supervision of an experienced physician in the use of antineoplastic agents
  • Higher risk of severe adverse reactions in patients with hepatic impairment
  • Not to be given to patients with neutrophil counts of <1500 cells/mm^3
  • Fatal gastrointestinal complications reported
  • Severe hypersensitivity reactions may occur
  • Treatment-related acute myeloid leukemia may occur

Overdose Effects

  • No known antidote for docetaxel overdose
  • Complications may include bone marrow suppression, peripheral neurotoxicity, and mucositis
  • Therapeutic G-CSF recommended for overdose

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store between 2°C and 25°C
  • Protected from light
  • Freezing does not adversely affect the product

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