Docetor 80 mg/vial (IV Infusion)
80 mg vial: ৳ 13,900.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Docetaxel trihydrate |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Breast Cancer
- Non-small Cell Lung Cancer
- Castration-Resistant Prostate Cancer
- Gastric Adenocarcinoma
- Squamous Cell Carcinoma of the Head and Neck
Pharmacology
- Antineoplastic agent
- Disrupts microtubular network
- Promotes assembly of tubulin
- Inhibits microtubule disassembly
Dosage & Administration
- Administer intravenously over 1 hr
- Dosage range: 60 mg/m^2 to 100 mg/m^2
- Specific dosages for different indications
- Premedicate with oral corticosteroids
Interaction
- CYP3A4 substrate
- Metabolism may be modified by concomitant administration of certain compounds
Contraindications
- Neutrophil counts < 1500 cells/mm^3
- History of severe hypersensitivity reactions to docetaxel or polysorbate 80
Side Effects
- Infections
- Neutropenia
- Anemia
- Hypersensitivity
- Thrombocytopenia
- Neuropathy
- Dysgeusia
- Fluid retention
- Pain
- Nausea
- Diarrhea
- Alopecia
- Skin reactions
- Myalgia
Pregnancy & Lactation
- Potential fetal harm
- No information on presence in human milk
Precautions & Warnings
- Administered under supervision of experienced physician
- Higher risk in patients with hepatic impairment
- Not for patients with neutrophil counts < 1,500 cells/mm^3
- Severe hypersensitivity reactions
- Treatment-related acute myeloid leukemia
Overdose Effects
- No known antidote
- Expected complications: bone marrow suppression, neurotoxicity, mucositis
- Therapeutic G-CSF recommended
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
Store between 2°C and 25°C, protected from light