Xelotan Plus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Pharmasia limited

Product Title

  • Xelotan Plus

Category

  • Antihypertensive Medication
  • Combination Antihypertensive Preparations

Description

  • Treatment of Hypertension
  • Reduction of Stroke Risk in Patients with Hypertension and Left Ventricular Hypertrophy
  • Pharmacological action of Losartan and Hydrochlorothiazide
  • Dosage guidelines for Hypertension and Severe Hypertension
  • Administration with or without food
  • Potential drug interactions
  • Contraindications related to hypersensitivity and anuria
  • Common side effects of the medication
  • Pregnancy and lactation considerations
  • Precautions and warnings for usage
  • Special population considerations such as renal and hepatic impairment, and pediatric use
  • Potential effects of overdose
  • Therapeutic class of the medication
  • Recommended storage conditions

Dosage Guidelines

  • For treatment of Hypertension
  • For treatment of Severe Hypertension
  • Antihypertensive effects attainment period
  • Initial dosage adjustment for elderly patients

Pharmacology

  • Angiotensin converting enzyme (ACE) inhibition
  • Vasoconstrictor and aldosterone-secreting effects of Angiotensin II
  • Thiazide diuretic action on electrolyte reabsorption and excretion
  • Renin-angiotensin system modulation
  • Effects on plasma volume and renin-aldosterone link

Interaction

  • Potential interactions of Losartan with other drugs
  • Effect of Thiazide diuretics when administered concurrently with specific drugs
  • Necessity of dosage adjustment for antidiabetic drugs when used with Hydrochlorothiazide
  • Additive effects or potentiation with other antihypertensive drugs
  • Effects on Hydrochlorothiazide absorption in the presence of anionic exchange resins

Contraindications

  • Hypersensitivity to any component of the product
  • Anuria
  • Hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension
  • Dizziness
  • Hyperkalaemia
  • Angioedema
  • Vertigo
  • Gastrointestinal disturbances
  • Angina
  • Palpitation
  • Edema
  • Dyspnoea
  • Headache
  • Sleep disorders
  • Malaise
  • Urticaria
  • Pruritus
  • Rash
  • Hepatitis
  • Atrial fibrillation
  • Cerebrovascular accident
  • Syncope
  • Paraesthesia
  • Pancreatitis
  • Anaphylaxis
  • Cough
  • Depression
  • Erectile dysfunction
  • Anemia
  • Thrombocytopenia
  • Hyponatremia
  • Arthralgia
  • Myalgia
  • Renal impairment
  • Rhabdomyolysis
  • Tinnitus
  • Photosensitivity
  • Vasculitis

Pregnancy & Lactation

  • Avoidance of use in pregnancy unless essential
  • Adverse effects on fetal and neonatal blood pressure control and renal function
  • Reports of skull defects and oligohydramnios
  • Not recommended during breastfeeding
  • Availability of alternative treatment options with better-established safety information

Precautions & Warnings

  • Hypersensitivity-related Angioedema
  • Periodic determination of serum electrolytes
  • Risk of hypokalemia development
  • Impaired renal function
  • Symptomatic hypotension

Special Population Considerations

  • Use in Patients with Renal Impairment
  • Use in Patients with Hepatic Impairment
  • Safety and effectiveness in pediatric patients not established

Overdose Effects

  • Manifestation of hypotension and tachycardia
  • Cardiac arrhythmia accentuation due to hypokalemia
  • Limited data available for overdosage in humans
  • Supportive treatment in case of symptomatic hypotension

Therapeutic Class

  • Combined Antihypertensive Preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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