Oxator 5 mg/ml (IV Infusion)
50 mg vial: ৳ 3,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxaliplatin |
| Company | Eskayef pharmaceuticals ltd |
Indications
- Adjuvant treatment of stage III colon cancer
- Treatment of advanced colorectal cancer
Pharmacology
- Formation of reactive species
- Inhibition of DNA replication and transcription
- Antitumor activity against colon carcinoma
Dosage & Administration
- Recommended administration every 2 weeks
- Adjuvant use recommended for 6 months
- Detailed Day 1 and Day 2 dosing regimen
Interaction
- No specific cytochrome P-450-based drug interaction studies
- Platinum-containing species elimination
- Potential nephrotoxic compound coadministration
Contraindications
- Contraindicated in patients with known allergy to oxaliplatin or other platinum compounds
Side Effects
- Peripheral sensory neuropathy
- Neutropenia
- Thrombocytopenia
- Nausea
- Increase in transaminases and alkaline phosphatase
- Diarrhea
- Emesis
- Fatigue
- Stomatitis
Pregnancy & Lactation
- Pregnancy Category D
- Potential fetal harm
- Advice for women of childbearing potential
- Excretion in human milk
Precautions & Warnings
- Grade 3/4 hypersensitivity allergic reactions
- Neurological toxicity monitoring
- Pulmonary toxicity association
- Hepatotoxicity investigation
- Cardiovascular toxicity
- QT prolongation and ventricular arrhythmias
Overdose Effects
- No known antidote for overdose
- Complications of overdose
- Adverse reactions observed in reported overdoses
- Monitoring and supportive treatment
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store in a cool & dry place
- Protected from light and moisture
- Keep out of reach of children