Paclitor 6 mg/ml (IV Infusion)
30 mg vial: ৳ 1,700.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paclitaxel |
| Company | Eskayef pharmaceuticals ltd |
Indications
- Treatment of advanced carcinoma of the ovary
- Adjuvant treatment of node-positive breast cancer
- Treatment of breast cancer after failure of combination chemotherapy
- First-line therapy of advanced or metastatic breast cancer
- Treatment of non-small cell lung cancer
- Second line treatment of AIDS related Kaposi's Sarcoma
- Treatment of Gastric Carcinoma
Pharmacology
- Promotes assembly of microtubules
- Stabilizes microtubules by preventing depolymerization
- Induces abnormal arrays of microtubules throughout the cell cycle
- Results in inhibition of normal dynamic reorganization of the microtubule network
Dosage & Administration
- Recommended premedication to prevent severe hypersensitivity reactions
- Specific dosage for first-line treatment of ovarian cancer
- Recommended doses for different types of breast carcinoma treatment
- Recommended dose for non-small cell lung cancer treatment
- Recommended dose for AIDS-related Kaposi's Sarcoma treatment
- Dose adjustment based on individual patient tolerance
Interaction
- Effect of cimetidine on Paclitor clearance
- Interaction with cisplatin leading to greater myelosuppression
- Sequence effects characterized by more profound neutropenic and stomatitis episodes with doxorubicin combination
- Metabolism catalyzed by cytochrome P450 isoenzymes
- Caution with concurrent administration of specific medicines known to inhibit or induce CYP2C8 or CYP3A4
Contraindications
- Contraindicated in patients with severe hypersensitivity reactions to paclitaxel
- Contraindicated during lactation
- Not to be used in patients with baseline neutrophils or platelets below certain levels
- Contraindicated in patients with severe hepatic impairment
- Contraindicated in patients with concurrent, serious, uncontrolled infections (Kaposi's Sarcoma)
Side Effects
- Common side effects including low blood counts, hair loss, pain in joints and muscles, neuropathy, nausea, vomiting, diarrhea, hypersensitivity reactions, fever, and more
- Rare side effects such as swelling of the feet or ankles, liver problems, low blood pressure, and darkening of the skin
Pregnancy & Lactation
- Category D in pregnancy
- Contraindicated during lactation
Precautions & Warnings
- Administration under the supervision of an experienced physician
- Potential for significant hypersensitivity reactions
- Monitoring for extravasation during drug administration
- Bone marrow suppression as the dose-limiting toxicity
- Severe cardiac conduction abnormalities reported rarely
Use in Special Populations
- Dose reduction for patients with severe neutropenia or neuropathy
- No recommended use in pediatric patients below 18 years
- Caution in patients with hepatic impairment
Overdose Effects
- No known antidote for Paclitor overdose
- Closely monitor patient and treat primary anticipated toxicities
Reconstitution
- Dilution of Paclitor Injection prior to infusion
- Recommended dilution in specific types of solution
- Physical and chemical stability of solutions for up to 27 hours at ambient temperature
Storage Conditions
- Storage below 30°C
- Protection from light
- Preparation of only freshly prepared solution