Danflex 25 mg (Capsule)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Dantrolene sodium
Company Opsonin pharma ltd
Also available as

Indications

  • Control of clinical spasticity
  • Management of upper motor neuronal disorders
  • Beneficial for functional rehabilitation
  • Not indicated for treatment of skeletal muscle spasm resulting from rheumatic disorders
  • Prevention or attenuation of signs of malignant hyperthermia
  • Prevent recurrence of malignant hyperthermia post crisis
  • Significant reduction in painful and/or disabling spasticity
  • Permits reduction in intensity and/or degree of nursing care required
  • Rids the patient of any annoying manifestation of spasticity considered important by the patient

Pharmacology

  • Produces relaxation by affecting the contractile response of skeletal muscle
  • Dissociates excitation-contraction coupling in skeletal muscle
  • Interferes with the release of calcium ions from the sarcoplasmic reticulum

Dosage & Administration

  • Gradual titration schedule for adults
  • Gradual titration schedule for pediatric patients
  • Maximum accepted dosage for adults
  • Maximum accepted dosage for pediatric patients
  • Preoperative administration for malignant hyperthermia
  • Post-crisis follow-up dosage for malignant hyperthermia

Interactions

  • Potential drowsiness with therapy
  • Concomitant administration of CNS depressants
  • Hepatotoxicity in women over 35 years on estrogen therapy

Contraindications

  • Active hepatic disease such as hepatitis and cirrhosis

Side Effects

  • Drowsiness
  • Dizziness
  • Weakness
  • General malaise
  • Fatigue
  • Diarrhea (transient & severe)
  • Necessity of temporary withdrawal in case of severe diarrhea

Pregnancy & Lactation

  • Pregnancy Category C
  • Use during pregnancy only if potential benefit justifies potential risk to fetus
  • Not to be used in nursing mothers

Precautions & Warnings

  • Therapy should be stopped if benefits are not evident within 45 days
  • Caution against driving a motor vehicle or participating in hazardous occupations
  • Exercise caution in concomitant administration of tranquilizing agents
  • Possible photosensitivity reaction
  • Potential for fatal and non-fatal liver disorders
  • Initial and subsequent liver function studies prior to and during therapy
  • Using with caution in patients with impaired pulmonary function or severely impaired cardiac function
  • Use with caution in patients with a history of liver disease or dysfunction

Use in Special Populations

  • Long-term safety in pediatric patients under the age of 5 years not established
  • Benefit-risk consideration for long-term use in pediatric patients important

Therapeutic Class

  • Centrally acting Skeletal Muscle Relaxants

Storage Conditions

  • Store in a cool & dry place
  • Protect from light

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