Flexiril 5 mg (Tablet)

Unit Price: ৳ 5.50 (3 x 10: ৳ 165.00)

Strip Price: ৳ 55.00

Medicine Details

Category	Details
Generic	Baclofen
Company	Everest pharmaceuticals ltd
Also available as	Flexiril 10 mg tablet

Indications

spasticity resulting from multiple sclerosis
flexor spasms and concomitant pain, clonus and muscular rigidity
skeletal muscle spasm resulting from rheumatic disorders
spinal cord injuries and other spinal cord diseases
cerebrovascular accidents or neoplastic or degenerative brain disease

Pharmacology

Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABAB receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.

Dosage & Administration

Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily
Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement. Daily maintenance dose-12 month-2 years: 10-20 mg (10-20 ml), 2 years-6 years: 20-30 mg (20-30 ml), 6 years-10 years: 30-60 mg (30-60 ml)

Interaction

Increased sedation may occur if Flexiril is taken with agents acting on the central nervous system, alcohol or synthetic opiates. The risk of respiratory depression is also increased
Combined treatment with Flexiril and antihypertensives is likely to increase the fall in blood pressure; therefore the dosage of antihypertensive medication should be adjusted accordingly
The concomitant administration of Flexiril and tricyclic antidepressants may potentiate the pharmacological effects of Flexiril resulting in pronounced muscular hypotonia
In patients with Parkinsons disease receiving treatment with Flexiril and levodopa and carbidopa, there have been several reports of mental confusion, hallucinations, headaches, nausea and agitation
The concurrent use of MAO inhibitors and Flexiril may result in increased CNS depressant effects. Caution is advised and the dosage of one or both agents should be adjusted accordingly
Caution should be exercised when administering Flexiril and magnesium sulphate or other neuromuscular blocking agents since a synergistic effect may theoretically occur

Contraindications

Baclofen is contraindicated in patients with hypersensitivity to any component of this product

Side Effects

Transient drowsiness
Daytime sedation
Dizziness
Weakness
Fatigue
Headache
Insomnia
Euphoria
Excitement
Depression
Confusion
Hallucinations
Paraesthesia
Nightmares
Muscle pain
Tinnitus
Slurred speech
Co-ordination disorder
Tremor
Rigidity
Dystonia
Ataxia
Blurred vision
Nystagmus
Strabismus
Miosis
Mydriasis
Diplopia
Dysarthria
Epileptic seizures
Respiratory depression
Hypotension
Dyspnoea
Palpitation
Chest pain
Syncope
Nausea
Constipation
Dry mouth
Anorexia
Taste disorder
Abdominal pain
Vomiting
Diarrhoea
Positive test for occult blood in stool
Urinary frequency
Enuresis
Urinary retention
Dysuria
Impotence
Inability to ejaculate
Nocturia
Haematuria
Rash
Pruritus
Ankle oedema
Excessive perspiration
Weight gain
Nasal congestion
Visual disturbances
Hepatic function disorders
Paradoxical increase in spasticity

Pregnancy & Lactation

Pregnancy category: B3
Info: Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen should only be administered to pregnant women when in the judgement of the physician concludes that the potential benefits outweigh the possible hazards. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected

Precautions & Warnings

Lower doses (approximately 5 mg per day) should be used for patients with impaired renal function or those undergoing chronic haemodialysis
Patients suffering not only from spasticity but also from psychotic disorders, schizophrenia, depressive or manic disorders or confusional states should be treated cautiously and closely monitored as exacerbations of these disorders may occur
In patients with epilepsy and muscle spasticity, Flexiril may be used under appropriate supervision and provided that adequate anticonvulsive therapy is continued
Flexiril should be used with caution in patients with or with a history of peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
Careful monitoring of respiratory and cardiovascular function is essential especially in patients with cardiopulmonary disease and respiratory muscle weakness
During treatment with Flexiril, neurogenic disturbances affecting emptying of the bladder may improve
In patients with preexisting sphincter hypertonia, acute retention of urine may occur
Flexiril has not significantly benefited patients with stroke
Appropriate laboratory tests should be performed periodically in patients with hepatic diseases or diabetes mellitus to ensure that no medicine induced changes in these underlying diseases have occurred

Overdose Effects

Gastric lavage is important in case of severe overdose

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children