Pangesic 325 mg+37.5 mg (Tablet)
Unit Price: ৳ 8.00 (5 x 6: ৳ 240.00)
Strip Price: ৳ 48.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Paracetamol tramadol hydrochloride |
| Company | Renata limited |
Indications and Usage
- Management of moderate to moderately severe pain in adults
- Short-term (five days or less) management of acute pain
Pharmacology
- Has analgesic and antipyretic properties
- Weak anti-inflammatory activity
- Thought to act primarily in the CNS
- Increases pain threshold by inhibiting COX-1, COX-2, and COX-3 enzymes
- Centrally acting synthetic opioid analgesic
- Two complementary mechanisms of action: binding to µ-opioid receptors and weak inhibition of norepinephrine and serotonin reuptake
Dosage and Administration
- Recommended dose for moderate to moderately severe pain: 1 or 2 tablets every 4 to 6 hours
- Recommended dose for short-term acute pain: 2 tablets every 4 to 6 hours
- Maximum of 8 tablets per day
- Can be administered without regard to food
Contraindications
- Hypersensitivity to tramadol, paracetamol, or opioids
- Contraindicated in situations where opioids are contraindicated
Side Effects
- Asthenia
- Fatigue
- Hot flushes
- Dizziness
- Headache
- Tremor
- Abdominal pain
- Constipation
- Diarrhea
- Dyspepsia
- Dry mouth
- Nausea
- Vomiting
- Anorexia
- Anxiety
- Confusion
- Euphoria
- Insomnia
- Nervousness
- Somnolence
- Pruritus
- Rash
- Increased sweating
Pregnancy and Lactation
- Pregnancy Category C
- Not recommended for obstetrical preoperative medication or post-delivery analgesia in nursing mothers
- Safety in infants and newborns not studied
Precautions and Warnings
- May impair mental or physical abilities
- Should not be taken with alcohol
- Avoid combination with other tramadol or paracetamol-containing products
- Use with caution when taking certain medications
Use in Special Populations
- Safety and effectiveness not studied in pediatric population
- Dose selection for elderly patients should be cautious
- Not studied in patients with impaired renal function
- Not recommended in patients with impaired hepatic function
Therapeutic Class
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Store in a cool and dry place
- Do not freeze
- Keep out of the reach of children