Histavil 5 mg/5 ml (Oral Solution)
60 ml bottle: ৳ 10.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Promethazine hydrochloride |
| Company | Pacific pharmaceuticals ltd |
Indications
- Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects
- Symptomatic treatment of allergic conditions of the respiratory tract and skin
- Sensitization reactions to drug or foreign proteins
- Sedation, allergic rhinitis, urticaria, and insomnia
- Adjunct in pre-operative sedation in surgery and obstetrics
- Pediatric sedative
Pharmacology
- Blocks postsynaptic mesolimbic dopaminergic receptors
- Exhibits α-adrenergic blocking effect
- Depresses the release of hypothalamic and hypophyseal hormones
- Competes with histamine for the H1-receptor
- Reduces stimuli to the brainstem reticular system
- Well absorbed from the gastrointestinal tract
- Clinical effects apparent within 20 minutes after oral administration
- Generally last four to six hours
- Metabolized by the liver to a variety of compounds
- Sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine
Dosage & Administration
- Adults: Initial dose one 25 mg tablet at night, may be increased to two or three 25 mg tablets at night if necessary
- In allergic conditions more frequent administration may be necessary
- Elderly: No specific dosage recommendations
- Children may be treated more conveniently by the elixir containing 5 mg/5 ml
- Specific dosages for antihistamine and sedative use in children
Interaction
- Enhances the action of anticholinergic agents, tricyclic antidepressants, sedatives, or hypnotics
- Interferes with immunologic urine pregnancy tests
- Should be discontinued at least 72 hours before skin tests using allergen extracts
Contraindications
- Contraindicated for use in children less than two years of age
- Hypersensitivity to promethazine or any excipients
- Not to be used in patients who are in a coma or suffering from CNS depression
- Avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days
Side Effects
- Nervous system disorders including somnolence, dizziness, headaches, and extrapyramidal effects
- Allergic reactions including urticaria, rash, pruritus, and anaphylaxis
- Photosensitivity reaction
- Anorexia, epigastric discomfort, and dry mouth
- Blurred vision and blood dyscrasias
- Urinary retention and psychiatric disorders like restlessness and nightmares
- Cardiac disorders including palpitations and arrhythmias
- Vascular disorders such as hypotension
- Hepatobiliary disorders like jaundice
- General disorders like tiredness
- Abuse potential - do not take for longer than 10 days
Pregnancy & Lactation
- Epidemiological evidence for safety in pregnancy but should be used only if essential
- Not recommended in the two weeks prior to delivery
- Prolonged neurological disturbances in the infant if given in high doses during late pregnancy
- Excreted in breastmilk with risks of neonatal irritability and excitement
Precautions & Warnings
- Avoided in children and adolescents with signs suggestive of Reye's syndrome
- May thicken lung secretions and impair expectoration in patients with asthma, bronchitis, or bronchiectasis
- Use with care in patients with severe coronary artery disease, narrow angle glaucoma, epilepsy, hepatic insufficiency, renal insufficiency, bladder neck obstruction, and pyloro-duodenal obstruction
Overdose Effects
- Symptoms of severe overdose variable in children and adults
- Supportive treatment with attention to respiratory and circulatory status
- Convulsions should be treated with suitable anticonvulsant
Therapeutic Class
- Anti-emetic drugs
- Miscellaneous sedatives & hypnotics
- Sedating Anti-histamine
Storage Conditions
Protect from light. Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician