Darven 5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | General pharmaceuticals ltd |
| Also available as |
Product Title
- Darven
Categories
- Medicine
- Hypertension Management
Description
- Darven is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Darven is increasingly used in patients with chronic kidney disease. Cilnidipine is a dihydropyridine calcium-channel blocker. Darven should be administered with care in patients with serious hepatic dysfunction, patients with a history of serious adverse reactions to calcium antagonists. Darven is contraindicated in patients with known sensitivity to Cilnidipine or any of the excipients or patients having cardiogenic shock, recent MI or acute unstable angina and severe aortic stenosis.
Dosage & Administration
- Adults: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily. Pediatric use: The safety of Cilnidipine in pediatric patients has not been established. Elderly use: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).
Pharmacology
- Cilnidipine is a dihydropyridine calcium-channel blocker. Cilnidipine binds to the dihydropyridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells via this channel, consequently causing vasodilation. Cilnidipine is considered to suppress the reflex increase in heart rate after blood pressure reduction.
Interaction
- Other anti-hypertensive, antipsychotics that cause hypotension, quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin
Contraindications
- Cilnidipine is contraindicated in patients with known sensitivity to Cilnidipine or any of the excipients or patients having cardiogenic shock, recent MI or acute unstable angina and severe aortic stenosis.
Side Effects
- Dizziness
- flushing
- headache
- hypotension
- peripheral oedema
- palpitations
- GI disturbances
- increased micturition frequency
- lethargy
- eye pain
- depression
Pregnancy & Lactation
- Cilnidipine should not be administered in pregnant women or women who have possibilities of being pregnant. It is also advisable to avoid the administration of Cilnidipine to nursing mothers. However, if the administration is indispensable, the patient should be instructed to discontinue lactation.
Precautions & Warnings
- Darven should be administered with care in the following patients: patients with serious hepatic dysfunction, patients with a history of serious adverse reactions to calcium antagonists.
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store below 30°C, protected from light and moisture. Keep away from reach out of the children.