Othera 20 mg (MUPS Tablet)

Unit Price: ৳ 11.00 (5 x 10: ৳ 550.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Aci limited
Also available as
Othera 40 mg tablet Othera 40 mg injection

Title

  • Othera MUPS Tablet

Category

  • Medicine
  • Pharmaceutical

Indications

  • Treatment of Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • Esomeprazole MUPS 20 Tablet
  • Esomeprazole MUPS 40 Tablet

Esomeprazole Content

  • 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
  • 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

MUPS

  • Abbreviation for Multiple-Unit Pellet System
  • Compacted into tablets
  • Combines advantages of tablets and pellet-filled capsules
  • Greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine
  • Rapid dissolution of enteric coating and drug release
  • Combination of fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Better than capsules in reducing esophageal residence time
  • Minimizes fluctuation in plasma concentration of drug
  • Rapid and uniform gastric emptying
  • Consistent and controlled pharmacological action
  • Reduction in variability in drug absorption and clinical response

Mode of Action

  • Inhibits gastric acid by blocking the proton pump of the gastric parietal cell
  • Effective for short-term treatment of gastric and duodenal ulcers

Dosage

  • For adult and children above 12 years
  • For children 1-11 years
  • For children below 1 year

Administration

  • Tablets should be swallowed whole with liquid
  • Can be dispersed in non-carbonated water if required
  • Pellets must not be chewed or crushed

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes
  • Interference with CYP2C19
  • Inhibition of gastric acid secretion
  • Potential interference with drug absorption affected by gastric pH

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Caution advised
  • Unknown presence in human breast milk

Precautions & Warnings

  • Careful use in severe liver dysfunction and severe renal impairment
  • Slight increase in the risk of hip, wrist, and spine fracture

Storage Conditions

  • Store in a cool & dry place below 25°C
  • Protect from light
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image

Common Questions

  • Uses of Othera 20 mg MUPS Tablet
  • Side effects of Othera 20 mg MUPS Tablet
  • Safety during pregnancy and breastfeeding
  • Onset of action
  • Quick Tips

Additional Information

  • Combination Therapy with Clarithromycin
  • No difference in types of related adverse events seen during maintenance treatment up to 12 months compared to short-term treatment

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