Protace-H 2.5 mg+12.5 mg (Tablet)

Title

• Ramipril and Hydrochlorothiazide Tablets

Categories

• Hypertension Medication
• Antihypertensive Drugs

Description

• An effective combination of Ramipril and Hydrochlorothiazide for the treatment of mild to moderate hypertension in patients who have been stabilized on the individual components given in the same proportion.

Dosage and Administration

• Dose titration guided by clinical effect
• Maximum daily dose: 10 mg ramipril and 50 mg hydrochlorothiazide

Pharmacology

• Ramipril is an angiotensin converting enzyme (ACE) inhibitor
• Hydrochlorothiazide is a thiazide diuretic

Interaction

• Combination with diuretics or other antihypertensive agents may potentiate the antihypertensive response
• May weaken the effectiveness of blood sugar lowering medications

Contraindications

• Hypersensitivity to ramipril, hydrochlorothiazide, or other thiazide diuretics
• History of hereditary angioneurotic edema
• Severe impairment of renal function

Side Effects

• Headache
• Dizziness
• Nausea
• Hypotension
• Cough
• Weakness
• Diarrhea

Pregnancy and Lactation

• Must be discontinued when pregnancy is detected
• Should not be used during breastfeeding

Precautions and Warnings

• Regular medical supervision required
• Caution necessary in patients with severe hypertension or heart failure
• Fluid or salt deficiency should be corrected before treatment

Use in Special Populations

• Dosage adjustment in renal impairment
• Safety and effectiveness in pediatric patients not established

Overdose Effects

• Clinical manifestations may include symptoms attributable to hypotension
• Electrolyte depletion and dehydration resulting from excessive diuresis

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Store in a cool and dry place, protected from light

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