Voriderm 200 mg/5 ml (Powder for Suspension)

40 ml bottle: ৳ 1,000.00

Medicine Details

Indications

  • Treatment of invasive aspergillosis
  • Treatment of candidemia and disseminated candidiasis
  • Treatment of esophageal candidiasis
  • Treatment of serious infections caused by specific fungal species
  • Treatment for patients intolerant of or refractory to other therapy

Pharmacology

  • Voriconazole is a triazole antifungal medication
  • Inhibits ergosterol synthesis
  • Binds and inhibits CYP450-dependent 14-alpha sterol demethylase
  • Depletes ergosterol in fungal cell membrane

Dosage & Administration

  • Oral administration instructions
  • Loading dose regimen for different body weights
  • Maintenance dose regimen for different body weights
  • Injection administration instructions for specific infections

Interaction

  • Interactions with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
  • Increased concentrations of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
  • Co-administration effects with specific drugs like Phenytoin and Efavirenz

Contraindications

  • Known hypersensitivity to Voriconazole or its components
  • Co-administration risks with specific drugs
  • Risk of loss of efficacy with certain co-administered drugs

Side Effects

  • Abdominal pain
  • Anemia
  • Blurred vision
  • Headache
  • Chest pain
  • Nausea
  • Diarrhea

Pregnancy & Lactation

  • Use during pregnancy justified only if potential benefit outweighs potential risk

Precautions & Warnings

  • Careful assessment for long-term exposure greater than 180 days
  • Association with squamous cell carcinoma of the skin in long-term treatment

Use in Special Populations

  • Efficacy not established in children under 12 years of age

Overdose Effects

  • No data available about overdose effects

Therapeutic Class

  • Belongs to the class of Other Antifungal preparations

Reconstitution

  • Instructions for reconstituting suspension
  • Shaking the bottle before adding water
  • Specific quantity of water to be added
  • Storage conditions for reconstituted suspension

Storage Conditions

  • Keep out of reach of children
  • Store in a dry place below 25°C and protected from light
  • Specific storage temperature for Voriderm powder for suspension

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