Voriderm 50 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of invasive aspergillosis
- Treatment of candidemia in nonneutropenic patients
- Treatment of disseminated candidiasis in skin, abdomen, kidney, bladder wall, and wounds
- Treatment of esophageal candidiasis
- Treatment of serious infections caused by Scedosporium apiospermum and Fusarium species
- Treatment for patients intolerant of or refractory to other therapy
Pharmacology
- Triazole antifungal medication
- Binds and inhibits ergosterol synthesis
- Inhibits CYP450-dependent 14-alpha sterol demethylase
- Results in depletion of ergosterol in fungal cell membrane
Dosage & Administration
- Use of voriconazole tablet and powder for suspension
- Oral administration at least one hour before or after a meal
- Different loading and maintenance dosages based on body weight
- Loading and maintenance dosages for invasive aspergillosis, candidemia in nonneutropenic patients, Scedosporiosis, and Fusariosis
Interaction
- Adjust dosage and monitor for adverse reactions with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Increase maintenance oral and intravenous dosage with co-administration of Phenytoin or Efavirenz
- Voriderm may increase concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
Contraindications
- Known hypersensitivity to Voriconazole or any other components
- Co-administration with specific drugs due to risk of serious adverse reactions or loss of efficacy
Side Effects
- Common side effects include abdominal pain, anemia, blurred vision, headache, chest pain, nausea, and diarrhea
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Should be used during pregnancy only if potential benefit justifies the potential risk to the fetus
Precautions & Warnings
- Long-term exposure requires careful assessment of benefit-risk balance
- Squamous cell carcinoma of the skin (SCC) reported in relation with long-term Voriderm treatment
Use in Special Populations
- Efficacy not established for children under 12 years of age
Overdose Effects
- No specific data available for overdose of Voriderm
Therapeutic Class
- Other Antifungal preparations
Reconstitution
- Instructions for reconstitution of suspension
- Shake the bottle well before adding water to loosen the powder
- Add 25 ml of boiled and cooled water to the bottle
- Shake vigorously until powder is completely mixed with the water
- Store reconstituted suspension between 15°C-30°C
- Discard suspension 14 days after reconstitution
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C and protected from light
- Store Voriderm powder for suspension between 2°C to 8°C