Allergan 5 mg/5 ml (Oral Solution)

100 ml bottle: ৳ 24.00

Medicine Details

Category	Details
Generic	Promethazine hydrochloride
Company	Cipla limited

Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects
Indicated in symptomatic treatment of allergic conditions of the respiratory tract and skin
Sensitization reactions to drug or foreign proteins, anaphylactic reactions
For sedation, allergic rhinitis, urticaria and insomnia
As an adjunct in pre-operative sedation in surgery and obstetrics
As a paediatric sedative

Blocks postsynaptic mesolimbic dopaminergic receptors in the brain
Exhibits strong α-adrenergic blocking effect
Depresses the release of hypothalamic and hypophyseal hormones
Competes with histamine for the H1-receptor
Muscarinic blocking effect responsible for antiemetic activity
Reduces stimuli to the brainstem reticular system
Well absorbed from the gastrointestinal tract
Clinical effects appear within 20 minutes after oral administration
Metabolized by the liver to a variety of compounds
Sulfoxides of promethazine and N-demethylpromethazine are predominant metabolites appearing in the urine

Initial dose one 25 mg tablet at night; may be increased to two or three 25 mg tablets at night if necessary
In allergic conditions more frequent administration may be necessary
Elderly: No specific dosage recommendations
Children may be treated more conveniently by the elixir containing 5 mg/5 ml
Specific dosage recommendations for antihistamine and sedative use in children

May enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative, or hypnotic
Alcohol should be avoided during drug treatment
May interfere with immunologic urine pregnancy tests
Should be discontinued at least 72 hours before skin tests using allergen extracts

Contraindicated for use in children less than two years of age
Hypersensitivity to promethazine or to any of the excipients
Not to be used in patients who are in a coma or suffering from CNS depression
To be avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days

Nervous system disorders including somnolence, confusion, dizziness, headaches, and extrapyramidal effects
Allergic reactions, including urticaria, rash, and pruritus
Photosensitivity reaction, anorexia, epigastric discomfort, dry mouth, and blurred vision
Blood dyscrasias, urinary retention, and cardiac and vascular disorders
Jaundice, tiredness, neuroleptic malignant syndrome, and potential promethazine abuse

Epidemiological evidence for the safety of promethazine in pregnancy
Caution advised in the two weeks prior to delivery and high doses during late pregnancy
Excreted in breastmilk with risks of neonatal irritability and excitement

To be avoided in children and adolescents with signs and symptoms suggestive of Reye's syndrome
May thicken or dry lung secretions and impair expectoration
Use with caution in patients with asthma, bronchitis, bronchiectasis, severe coronary artery disease, narrow angle glaucoma, epilepsy, hepatic insufficiency, renal insufficiency
Caution needed in patients with bladder neck or pyloro-duodenal obstruction

Symptoms of severe overdose include excitation, ataxia, incoordination, athetosis, hallucinations, drowsiness, and coma
Convulsions may occur and treated with diazepam or other suitable anticonvulsant
Supportive treatment with attention to respiratory and circulatory status