Deloxi 20 mg (Capsule (Delayed Release))

Unit Price: ৳ 7.00 (6 x 6: ৳ 252.00)

Strip Price: ৳ 42.00

Medicine Details

Category	Details
Generic	Duloxetine hydrochloride
Company	Eskayef pharmaceuticals ltd
Also available as	Deloxi 60 mg dr capsule

Indications

Major Depressive Disorder (MDD)
Generalized Anxiety Disorder (GAD)
Diabetic Peripheral Neuropathic Pain (DPNP)
Fibromyalgia
Chronic Musculoskeletal Pain

Pharmacology

Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Less potent inhibitor of dopamine reuptake. No significant affinity for various receptors. Does not inhibit monoamine oxidase (MAO). Well absorbed. Elimination mainly through hepatic metabolism.

Dosage & Administration

Specific starting, target, and maximum doses for different conditions
Benefit from starting at 30 mg once daily
Gradual dose reduction recommended to avoid discontinuation symptoms

Interaction

Metabolism by CYP1A2 and CYP2D6 isozymes. Co-administration with inhibitors of these isozymes can affect concentration of the product. Examples of drugs inhibiting CYP1A2 metabolism: fluvoxamine, cimetidine, quinolone antimicrobials. Concomitant use with potent inhibitors of CYP2D6 may result in higher concentrations.

Contraindications

Known hypersensitivity to the drug or inactive ingredients
Not approved for use in treating bipolar depression
Not recommended in patients with substantial alcohol use or evidence of chronic liver disease
Use with caution in patients with controlled narrow-angle glaucoma

Side Effects

Nausea
Dizziness
Dry mouth
Constipation
Decreased appetite
Fatigue
Somnolence
Increased sweating
Hyperhidrosis
Asthenia
Slight increase in blood pressure
No clinically significant differences observed for QT, PR, and QRS intervals between treated and placebo groups

Pregnancy & Lactation

Pregnancy: Category C
Labor and Delivery: Effect on labor and delivery in humans is unknown
Lactation: Unknown excretion into human milk, nursing not recommended

Precautions & Warnings

Monitor patients for clinical worsening, suicidality, and unusual changes in behavior
Measure blood pressure prior to initiating treatment and periodically throughout treatment
Caution about risk of bleeding with concomitant use of the product and certain drugs
Use cautiously in patients with a history of mania or seizure disorder

Use in Special Populations

Safety and efficacy in pediatric patients have not been established

Overdose Effects

Limited clinical experience with overdose. No specific antidote. General measures employed in overdose management for any drug. Monitoring of airway, oxygenation, ventilation, cardiac rhythm, and vital signs. Gastric lavage and activated charcoal may be indicated