Olmesta M 5 mg+40 mg (Tablet)

Unit Price: ৳ 20.00 (2 x 14: ৳ 560.00)
Strip Price: ৳ 280.00

Medicine Details

Category Details
Generic Amlodipine besilate olmesartan medoxomil
Company Eskayef pharmaceuticals ltd
Also available as
Olmesta m 5 mg tablet

Indications

  • Treatment of hypertension alone or with other antihypertensive agents
  • Initial therapy in patients likely to need multiple antihypertensive agents
  • Individualized decision based on baseline blood pressure and target goal

Pharmacology

  • Amlodipine - calcium channel blocker
  • Greater effect on vascular smooth muscle cells than on cardiac muscle cells
  • Peripheral arterial vasodilator
  • Olmesartan Medoxomil - blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Selective blocker of the AT1 receptor
  • Does not inhibit ACE

Dosage & Administration

  • Substitute individually titrated components for patients on Amlodipine and Olmesartan Medoxomil
  • Initial therapy with 5/20 mg once daily for 1 to 2 weeks
  • Titrate up to a maximum of 10/40 mg once daily
  • Lower starting dose of Amlodipine for elderly patients

Interaction

  • Attenuation of antihypertensive effect by NSAIDs including selective COX-2 inhibitors
  • Close monitoring of blood pressure, renal function, and electrolytes for patients on combination therapy

Contraindications

  • Cannot be co-administered with Aliskiren in patients with diabetes

Side Effects

  • Peripheral edema
  • Headache
  • Flushing
  • Dizziness
  • Sprue-like enteropathy

Pregnancy & Lactation

  • Pregnancy Category D
  • Avoid use in 2nd and 3rd trimester
  • Potential fetal death
  • Discontinue in pregnancy
  • Unknown excretion in human milk
  • Consideration for nursing mothers

Precautions & Warnings

  • Use with caution in volume- or salt-depleted patients
  • Vasodilation in patients with severe aortic stenosis
  • Increased risk in patients with severe obstructive coronary artery disease

Use in Special Populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety or effectiveness in geriatric patients
  • No studies in patients with renal impairment
  • Not recommended for hepatically impaired patients

Overdose Effects

  • No information available on overdose in humans

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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