Priocin 500 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythromycin oral |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Upper respiratory tract infections
- Lower respiratory tract infections
- Ear infections
- Eye infections
- Skin and Soft tissue infections
- Gastrointestinal tract infections
- Prophylaxis
- Other infections
Description
Belongs to the macrolides group of antibiotics
Micro-organisms Susceptible to Priocin
- Gram (+)ve : Cocci and bacilli
- Gram (-)ve : Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis
- Other micro-organisms : Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum
Pharmacology
- Mode of Action: Inhibits microsomal protein synthesis in susceptible organisms
- Specific Binding: To the 50S subunit or 70S ribosome
- Absorption: Destroyed by acid and is administered in the form of stable ester
- Distribution: Widely distributed throughout body tissue and fluids with some retention in the liver and spleen
- Excretion: 5-15% excreted in the urine, also crosses the placenta and is excreted in the milk
Dosage & Administration
- Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections
- Elderly: No special dosage recommendation
- Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosage
- Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses
Interaction
Use with theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity
Contraindications
Known hypersensitivity to Erythromycin
Side Effects
- Allergic reactions are rare and mild
- Anaphylaxis has occurred
- Abdominal discomfort after oral administration, sometimes with nausea and vomiting
Pregnancy & Lactation
Caution should be exercised when prescribing this drug to pregnant patients and lactating mothers since erythromycin crosses the placental barrier and is excreted in breast milk
Precautions & Warnings
Should be given with care in patients with impaired hepatic function, as Priocin is excreted principally in the bile
Overdose Effects
Priocin should be discontinued, prompt elimination of unabsorbed drug, not removed by peritoneal dialysis or haemodialysis
Therapeutic Class
Anti-diarrhoeal Antimicrobial drugs, Macrolides
Reconstitution
Shake the suspension well before each use, store in a cool and dry place, refrigerate and discard after 7 days
Storage Conditions
Keep below 25°C temperature, away from light & moisture, keep out of the reach of children