Priocin 125 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythromycin oral |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Upper respiratory tract infections
- Lower respiratory tract infections
- Ear infections
- Eye infections
- Skin and Soft tissue infections
- Gastrointestinal tract infections
- Prophylaxis
- Other infections
Antibiotic Group
Macrolides
Micro-organisms Susceptibility
- Gram (+)ve: Cocci and bacilli
- Gram (-)ve: Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis
- Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum
Pharmacological Action
Bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell
Absorption
Erythromycin base is destroyed by acid and is therefore administered in the form of stable ester
Blood Concentration
Peak serum concentrations of 0.9 to 1.4 or 0.4 to 1.8 mg/ml
Distribution
Widely distributed throughout body tissue and fluids with some retention in the liver and spleen
Excretion
5 to 15 % of the dose of erythromycin excreted in the urine
Dosage for Adult and Children over 8 years
250-500 mg every six hours for mild to moderate infections
Dosage for Elderly
No special dosage recommendation
Dosage for Children aged 2 to 8 years
250 mg every six hours or 30-50 mg/kg body weight per day
Dosage for Infants and Children upto 2 years
500 mg in divided doses or 30-50 mg/kg body weight in divided doses
Interaction with Theophylline
May be associated with an increase of serum theophylline levels and potential theophylline toxicity
Contraindications
Known hypersensitivity to Erythromycin
Side Effects
- Allergic reactions
- Abdominal discomfort
- Nausea
- Vomiting
Pregnancy & Lactation
Erythromycin crosses the placental barrier and is excreted in breast milk
Precautions & Warnings
Given with care in patients with impaired hepatic function
Overdose Effects
Should be discontinued; handled with prompt elimination of unabsorbed drug
Therapeutic Class
Anti-diarrhoeal Antimicrobial drugs, Macrolides
Reconstitution Directions
Shake the bottle to loosen powder; add boiled and cooled water to the dry powder of the bottle
Storage Conditions
Keep below 25°C temperature, away from light & moisture; keep out of the reach of children