Laxpru 1 mg (Tablet)

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Prucalopride succinate
Company Team pharmaceuticals ltd
Also available as
Laxpru 2 mg tablet

Indications

  • Symptomatic treatment of chronic constipation in adults

Pharmacology

  • Selective stimulator of 5-HT4 receptors
  • Stimulates motility in the gastrointestinal tract
  • Causes release of acetylcholine
  • Propulsion of luminal content

Dosage & Administration

  • 2 mg once daily for adults
  • 1 mg once daily for older people
  • Not recommended for children

Interaction

  • Low interaction potential with CYP-mediated metabolism
  • Weak substrate for P-glycoprotein
  • Inhibition by ketoconazole, verapamil, cyclosporine A, and quinidine
  • No clinically relevant effects on the pharmacokinetics of certain drugs

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Renal impairment requiring dialysis

Side Effects

  • Frequently reported adverse reactions include headache, abdominal pain, nausea, and diarrhea
  • Majority of adverse events are mild to moderate in intensity

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Women of childbearing potential should use effective contraception
  • Not recommended during breastfeeding based on animal studies

Precautions & Warnings

  • Dose adjustment for severe renal impairment
  • Limited data in patients with severe hepatic impairment
  • Reduced efficacy of oral contraceptives in case of severe diarrhea
  • Contains lactose, caution for patients with rare hereditary problems

Use in Special Populations

  • Dose adjustment for severe renal impairment and severe hepatic impairment
  • No dose adjustment for mild to moderate renal or hepatic impairment

Overdose Effects

  • Symptoms include headache, nausea, and diarrhea
  • No specific treatment available
  • Require correction of electrolyte disturbances in case of extensive fluid loss

Therapeutic Class

  • Osmotic purgatives

Storage Conditions

  • Store at room temperature below 30°C
  • Dispense in original bottle with desiccant

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