Emfogen M 5 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company General pharmaceuticals ltd
Also available as
Emfogen m xr 5 mg tablet Emfogen m xr 10 mg tablet Emfogen m xr 25 mg tablet Emfogen m 5 mg tablet Emfogen m 125 mg tablet Emfogen m 125 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • Insufficiently controlled on maximally tolerated dose of Metformin alone
  • Combination therapy with other medicinal products for diabetes
  • Already being treated with Empagliflozin and Metformin separately

Pharmacology

  • Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
  • Reduces renal reabsorption of filtered glucose
  • Lowers renal threshold for glucose
  • Increases urinary glucose excretion
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Take twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
  • Extended-release formulations
  • Assess renal function before initiating
  • Not recommended for pediatric patients under 18 years of age

Interaction

  • Diuretics
  • Insulin or Insulin Secretagogues
  • Positive Urine Glucose Test
  • Drugs that Reduce Metformin Clearance
  • Carbonic Anhydrase Inhibitors
  • Drugs Affecting Glycemic Control
  • Alcohol

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Diseases causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia
  • Headache
  • Hypoglycemia
  • Vaginal moniliasis
  • Volume depletion
  • Urticaria
  • Diabetic ketoacidosis

Pregnancy & Lactation

  • Potential risk to fetus
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic Acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity observed at high doses
  • Hypoglycemia and lactic acidosis
  • Treatment should be initiated based on patient's clinical status
  • Haemodialysis for lactate and Metformin removal

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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