Olzap 10 mg (Tablet)
Unit Price: ৳ 4.54 (3 x 14: ৳ 190.68)
Strip Price: ৳ 63.56
Medicine Details
| Category | Details |
|---|---|
| Generic | Olanzapine |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of schizophrenia
- Maintenance of schizophrenia
- Treatment of related psychoses
- Treatment of positive symptoms
- Treatment of negative symptoms
- Treatment of manic episodes in bipolar disorder
- Treatment of mixed episodes in bipolar disorder
- Treatment of bipolar disorder with psychotic features
- Treatment of rapid cycling course in bipolar disorder
Pharmacology
- Affinities for serotonin 5HT2A/2C
- Affinities for serotonin 5HT3
- Affinities for dopamine D1
- Affinities for dopamine D2
- Affinities for cholinergic muscarinic receptors M1-M5
- Affinities for alpha 1 adrenergic receptors
- Affinities for histamine H1 receptors
- Unknown mechanism of action
- Well absorbed after oral administration
- Reaches peak plasma concentrations within 5 to 8 hours
- Absorption not affected by food
- Not mutagenic
- Not clastogenic
- Not carcinogenic
Dosage
- Initial dose of 5-10 mg once daily for schizophrenia and bipolar disorder
- Daily dosage may be adjusted within the range of 5-20 mg
- Maximum dose is 20 mg daily for schizophrenia and bipolar disorder
- Initial dose of 15 mg once daily for monotherapy for mania
- Daily dosage may be adjusted within the range of 5-20 mg
- Maximum dose is 20 mg daily for monotherapy for mania
Administration
- Can be given without regard to meals
- Gradual tapering of the dose should be considered while discontinuing
Interaction
- May antagonize the effects of levodopa and dopamine agonists
- Drugs that induce CYP1A2 or glucoronyl transferase enzymes may increase clearance
- Inhibitors of CYP1A2 may inhibit elimination
- Carbamazepine may increase clearance
- Activated charcoal reduces oral bioavailability by 50-60%
- Caution should be taken when administered with centrally acting drugs and alcohol
Contraindications
- Known hypersensitivity to any ingredient
- Known risk for narrow-angle glaucoma
Side Effects
- Somnolence
- Weight gain
- Increased appetite
- Elevated glucose levels
- Elevated triglyceride levels
- Dizziness
- Akathisia
- Parkinson's disease
- Dyskinesia
- Orthostatic hypotension
- Anticholinergic effects including constipation and dry mouth
- Asthenia
- Edema
- Photosensitivity reaction
Pregnancy & Lactation
- Use in pregnancy only if potential benefits justify potential risk to the foetus
- No report of teratogenicity
- Patients should not breastfeed while taking
Precautions & Warnings
- Cautious use in patients with history of seizures
- Cautious use in patients with low leukocyte and/or neutrophil counts
- Cautious use in conditions associated with seizures
- Cautious use in drug-induced bone marrow depression/toxicity
- Cautious use in hypereosinophilic conditions
- Cautious use in impaired hepatic function
- Cautious use in patients using hepatotoxic medicines
- Cautious use in patients using centrally acting drugs
- Cautious use in patients using medicines known to increase QT interval
- Caution patients about operating hazardous machinery, including motor vehicles
Use in Special Populations
- Not studied in subjects under 18 years of age
- Starting dose of 5 mg/day for elderly patients (age 65 and over)
- Starting dose of 5 mg/day for patients with hepatic or renal impairment
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep below 30°C
- Keep away from light and moisture
- Keep out of the reach of children