Cardival Plus 80 mg+12.5 mg (Tablet)

Indications

• Treatment of hypertension

Pharmacology

• Contains Valsartan, an angiotensin receptor blocker
• Contains Hydrochlorothiazide, a thiazide diuretic
• Blocks angiotensin II receptor
• Dilates blood vessels and reduces blood pressure
• Specific angiotensin II antagonist

Dosage & Administration

• Combination therapy for uncontrolled hypertension
• Maximum dose of Valsartan and Hydrochlorothiazide
• No initial dosage adjustment for elderly
• Not established for pediatric use

Interaction

• Potential interactions with diuretics
• Potential interaction with agents increasing serum potassium
• Potential interaction with lithium salts
• Possible interactions with alcohol, barbiturates, narcotics
• May affect absorption of other drugs such as cholestyramine and colestipol resins

Contraindications

• Hypersensitivity to any component of the product
• Anuria
• Hypersensitivity to sulfonamide-derived drugs

Side Effects

• Rare side effects
• Common side effects include headache, dizziness, fatigue, abdominal pain, cough, diarrhea, nausea
• Potential side effects such as hyperkalemia, impotency, reduced renal function, allergic reactions, dyspnea, constipation, back pain, muscle cramps, rash, anxiety, insomnia, vertigo, hypotension

Pregnancy & Lactation

• Not recommended for use in pregnancy
• Not known if excreted in human milk

Precautions & Warnings

• Exercise caution in patients with impaired hepatic function
• Exercise caution in patients with impaired renal function
• Caution in initiating therapy in patients with heart failure and post-myocardial infarction

Use in Special Populations

• Usual therapy regimens for patients with creatinine clearance >30 ml/min
• Loop diuretics preferred for patients with severe renal impairment
• Care needed in patients with hepatic impairment

Overdose Effects

• Manifestations of overdosage include hypotension, tachycardia, bradycardia
• Management of Valsartan overdose with supine position and intravenous infusion of normal saline
• Management of Hydrochlorothiazide overdose for electrolyte depletion and potential cardiac arrhythmias

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Store between 15-30°C

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