Glypressin 1 mg/8.5 ml (IV Injection)

8.5 ml solution: ৳ 2,309.00 (5's pack: ৳ 11,545.00)

Medicine Details

Category Details
Generic Terlipressin acetate
Company Ferring pharmaceuticals ltd

Indications

  • Short term management of bleeding oesophageal varices
  • Emergency treatment of type 1 hepatorenal syndrome

Dosage & Administration

  • Initial i.v. injection of 2 mg terlipressin acetate every 4 hours
  • Adjustable dosage based on body weight and adverse effects
  • 3-4 mg terlipressin acetate i.v. every 24 hours for type 1 hepatorenal syndrome
  • Standard average duration of treatment: 10 days

Interaction

  • Increased hypotensive effect with non-selective beta-blockers
  • Lowered heart rate and cardiac output with concomitant bradycardiac effect medications
  • Extreme caution with medications that can prolong the QT interval
  • Potential triggering of 'torsade de pointes'
  • Caution with medications causing hypokalaemia or hypomagnesemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contraindicated in pregnancy

Side Effects

  • Paleness
  • Increased blood pressure
  • Abdominal pain
  • Nausea
  • Diarrhoea
  • Headache

Pregnancy & Lactation

  • Contraindicated during pregnancy
  • Potential harmful effects on pregnancy and foetus
  • Unknown excretion in human breast milk
  • Risk to the suckling child cannot be excluded

Precautions & Warnings

  • Regular monitoring and control of various parameters during treatment
  • Caution in patients with cardiac, pulmonary, or vascular disease
  • Not recommended for use in septic shock with low cardiac output
  • Avoid local necrosis with intravenous administration
  • Caution with predisposing factors for QT interval prolongation and ventricular arrhythmias
  • Ascertain acute functional renal failure prior to use for hepatorenal syndrome
  • Exercise caution in paediatric and elderly patients
  • Contains 1.33 mmol of sodium per ampoule

Use in Special Populations

  • No recommended dosage available for elderly or paediatric patients

Overdose Effects

  • Risk of severe circulatory adverse effects with exceeded dose
  • Control elevated blood pressure with clonidine i.v.
  • Treat bradycardia with atropine

Therapeutic Class

  • Other preparations

Storage Conditions

  • Refrigeration at 2-8°C
  • Protect from light by storing in outer carton

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