Tygacil 50 mg/vial (IV Infusion)

Title

• Tygacil

Categories

• Antibacterial agent
• Intravenous medication
• Glycylcycline

Description

• Glycylcycline antibacterial agent for intravenous infusion
• Inhibits protein translation in bacteria by binding to the 30S ribosomal subunit
• Blocks entry of amino-acyl tRNA molecules into the A site of the ribosome
• Prevents incorporation of amino acid residues into elongating peptide chains
• No cross-resistance observed between Tygacil and other antibacterials

Indications

• Complicated skin and skin structure infections
• Complicated intra-abdominal infections
• Community-acquired bacterial pneumonia

Pharmacology

• Inhibits protein translation in bacteria by binding to the 30S ribosomal subunit
• Carries a glycylamido moiety attached to the 9-position of minocycline
• Not affected by tetracycline resistance mechanisms
• In vitro and in vivo activity against a broad spectrum of bacterial pathogens
• No cross resistance observed with other antibiotics
• Considered bacteriostatic

Dosage and administration

• Recommended duration of treatment for different types of infections
• Recommended daily dose for adults
• Intravenous administration over approximately 30 to 60 minutes
• No established safety and effectiveness for pediatric patients below 18 years
• No unexpected overall differences in safety or effectiveness in geriatric use

Interaction

• Interaction with Digoxin and Warfarin

Contraindications

• Contraindicated in patients with known hypersensitivity to any components of this product

Side effects

• Nausea and vomiting as common treatment-emergent adverse events
• Injection site inflammation and pain
• Septic shock
• Allergic reaction
• Chills
• Thrombophlebitis
• Bradycardia
• Tachycardia
• Vasodilatation
• Anorexia
• Dry mouth
• Hypoglycemia
• Hyponatremia
• Prolonged prothrombin time
• Eosinophilia
• Thrombocytopenia
• Vaginal moniliasis
• Vaginitis
• Leukorrhea

Pregnancy and lactation

• Use during pregnancy if the potential benefit justifies the potential risk to the fetus
• Caution should be exercised when administered to a nursing woman

Precautions and warnings

• Structurally similar to Tetracycline-class antibiotics
• Administered with caution in patients with known hypersensitivity to Tetracycline-class antibiotics

Overdose effects

• No specific information available on the treatment of overdosage
• Increased incidence of nausea and vomiting with intravenous administration at a single dose of 300 mg over 60 minutes in healthy volunteers

Therapeutic class

• Tetracycline group of drugs

Reconstitution

• Reconstitution process with 0.9% Sodium Chloride Injection
• Gentle swirling until the drug dissolves
• Withdrawal and addition to intravenous bag for infusion
• Maximum concentration of IV solution should be 1 mg/ml
• Compatible with specific IV fluids

Storage conditions

• Refrigeration before reconstitution (2-8°C)
• Do not freeze
• Stability of reconstituted solution at room temperature and refrigerated state

Related Brands

• Tegalon 50 mg/vial (IV Infusion) - healthcare-pharmaceuticals-ltd