Topiclo 0.05% (Lotion)

60 ml bottle: ৳ 200.00

Medicine Details

Category	Details
Generic	Clobetasol propionate
Company	Eskayef pharmaceuticals ltd
Also available as	Topiclo 005 cream Topiclo 005 ointment Topiclo 005 spray

Indications

Psoriasis (excluding widespread plaque psoriasis)
Recalcitrant dermatoses
Lichen planus
Discoid lupus erythematosus
Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

Very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties

Dosage

Super-high potency topical corticosteroids; treatment should be limited to 2 consecutive weeks
Cream and Ointment: Apply a thin layer twice daily, maximum weekly dose should not exceed 50 gm/week
Spray: Apply once or twice daily to affected areas of the scalp, total dose applied should not exceed 50 ml weekly
Shampoo: Apply to the dry scalp once a day, treatment should be limited to 4 consecutive weeks
Scalp Solution: Apply once or twice daily to affected areas of the scalp, total dose applied should not exceed 50 ml weekly

Administration

Route of administration: Cutaneous. Creams are appropriate for moist or weeping surfaces, while ointments are appropriate for dry, lichenified, or scaly lesions

Interaction

Co-administered drugs that can inhibit CYP3A4 may inhibit the metabolism of corticosteroids leading to increased systemic exposure

Contraindications

Rosacea, acne vulgaris, and perioral dermatitis
Hypersensitivity to the preparation
Not indicated for infected skin lesions, perianal and genital pruritus
Dermatoses in children under one year of age

Side Effects

Prolonged use or treatment of extensive areas can result in systemic absorption. Local atrophic changes, pustular form of psoriasis, pigmentation changes, and hypertrichosis reported

Pregnancy & Lactation

Limited data in pregnant women, caution should be exercised during pregnancy and lactation

Precautions & Warnings

Long-term continuous therapy should be avoided, particularly in infants and children
Atrophic changes may occur after prolonged treatment on the face
Care needed to prevent entry into the eye when applied to eyelids
Appropriate anti-microbial therapy should be used for inflammatory lesions

Use in Special Populations

Long-term continuous topical corticosteroid therapy should be avoided in infants and children under 12 years of age

Overdose Effects

Acute overdosage is unlikely. Chronic over-dosage may lead to features of hypercortisolism