Vedilol 6.25 mg (Tablet)
Unit Price: ৳ 3.00 (4 x 10: ৳ 120.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Title
- Vedilol
Categories
- Medicine
- Pharmaceutical
Description
- Medication for the treatment of heart failure
- Non-selective antagonism of β-adrenergic receptors
- Possesses appreciable α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Used in the treatment of hypertension, angina pectoris, and congestive heart failure
Indications
- Treatment of mild, moderate, or severe heart failure of ischemic or cardiomyopathic origin
- Conjunction with digitalis, diuretics, and ACE inhibitor
- Reduction of disease progression as evidenced by cardiovascular death, cardiovascular hospitalization, or need for adjustment of other heart failure medications
- Use in patients unable to tolerate an ACE inhibitor or not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- Appreciable α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Increased to 25 mg once daily if necessary
- Usual dose of 25 mg once daily for hypertension
- Recommended dose of 12.5 mg twice daily for initiation of angina pectoris therapy
- Recommended dose of 25 mg twice daily for angina pectoris therapy
- Initial dose of 3.125 mg twice daily for heart failure
- Maximum dose of 25 mg twice daily in patients less than 85 kg body-weight and 50 mg twice daily in patients over 85 kg
Interaction
- Vedilol taken together with digoxin resulted in significantly increased levels of digoxin 24 hours later
- Rifampin resulted in a 60% decrease in Cmax and AUC
- Vedilol did not alter the in vitro plasma protein binding of warfarin
- β-receptor antagonists potentiate the pressor reaction which may follow the sudden withdrawal of treatment with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome (unless a permanent pacemaker is in place)
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral edema
- Painful extremities
- Dry mouth
- Dry eyes
- Eye irritation
- Disturbed vision
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- AV block
- Exacerbation of intermittent claudication or Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Heart failure
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not recommended during breast-feeding
- No studies performed in lactating women
- Excreted in breast milk
- Not recommended during pregnancy
- Carvedilol crosses the placental barrier
Precautions & Warnings
- Take caution in hepatic impairment
- Monitor clinical status after initiation
- Monitor clinical status after increasing each dose
- Ensure renal function and heart failure are not deteriorating before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children