Co-Diovan 160 mg+12.5 mg (Tablet)
Unit Price: ৳ 66.20 (2 x 14: ৳ 1,853.60)
Strip Price: ৳ 926.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Valsartan hydrochlorothiazide |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Treatment of hypertension
Pharmacology
- Oral medication
- Angiotensin receptor blockers
- Vasoconstriction inhibition
- Blood pressure reduction
- Specific angiotensin II antagonist
- Diuretic effect
- Electrolyte excretion
- Renal tubular mechanism effect
- Plasma volume reduction
- Aldosterone secretion increase
- Potassium loss increase
- Lack of effect on other hormone receptors
Dosage & Administration
- Once daily combination therapy
- Dosage limit for maximum efficacy
- No initial dosage adjustment for elderly
- Safety and effectiveness not established for pediatric use
Interaction
- Interaction with diuretics
- Potassium level impact
- Lithium salts clearance reduction
- Interaction with warfarin and digoxin
- Interaction with alcohol, barbiturates, narcotics
- Antidiabetic drug dosage adjustment
- Additive effect with other antihypertensive drugs
- Impairment of Hydrochlorothiazide absorption in the presence of anionic exchange resins
Contraindications
- Hypersensitivity to any component
- Anuria
- Hypersensitivity to sulfonamide-derived drugs
Side Effects
- Rare occurrence
- Common side effects include headache, dizziness, fatigue, abdominal pain, cough, nausea
- Possible hyperkalemia, impotency, reduced renal function, allergic reactions, dyspnea, constipation, muscle cramps, rash, anxiety, insomnia, vertigo
- Potential for hypotension
Pregnancy & Lactation
- Contraindicated in pregnancy
- Warning against use in 2nd and 3rd trimester
- Unknown excretion in human milk
Precautions & Warnings
- Hepatic function impairment caution
- Renal function impairment caution
- Caution in heart failure and myocardial infarction patients
Use in Special Populations
- Usual regimen for creatinine clearance >30 ml/min
- Preferential use of loop diuretics in more severe renal impairment
- Care for patients with hepatic impairment
Overdose Effects
- Manifestations of Valsartan overdosage
- Manifestations of Hydrochlorothiazide overdosage
- Treatment for excessive hypotension
- Electrolyte depletion signs and symptoms
- Possible accentuation of cardiac arrhythmias in the presence of digitalis
- Uncertainty of Hydrochlorothiazide removal by hemodialysis
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Store between 15-30°C